人绒毛膜促性腺激素抑制蜕膜化的人子宫内膜基质细胞中的胰岛素样生长因子结合蛋白-1和催乳素。
Human chorionic gonadotropin inhibits insulin-like growth factor-binding protein-1 and prolactin in decidualized human endometrial stromal cells.
作者信息
Fluhr Herbert, Krenzer Stefanie, Deperschmidt Margarita, Zwirner Manfred, Wallwiener Diethelm, Licht Peter
机构信息
Division of Gynecological Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynecology, University of Tübingen, Tübingen, Germany.
出版信息
Fertil Steril. 2006 Jul;86(1):236-8. doi: 10.1016/j.fertnstert.2005.12.031.
Recent data clearly show that hCG, as one of the first hormonal signals of the embryo, is involved in the modulation of endometrial receptivity in the secretory phase. Here we report a significant dose- and time-dependent inhibition of insulin-like growth factor-binding protein-1 and prolactin by hCG in human endometrial stromal cells after decidualization in vitro-findings that further underline the role of hCG in the endometrial milieu during early implantation.
近期数据清楚地表明，人绒毛膜促性腺激素（hCG）作为胚胎最早的激素信号之一，参与分泌期子宫内膜容受性的调节。在此我们报告，体外蜕膜化后人子宫内膜基质细胞中，hCG对胰岛素样生长因子结合蛋白-1和催乳素具有显著的剂量和时间依赖性抑制作用——这些发现进一步强调了hCG在早期着床期间子宫内膜环境中的作用。
Zotero 插件