吸烟会降低体外受精/卵胞浆内单精子注射患者的子宫内膜厚度。
Smoking Decreases Endometrial Thickness in IVF/ICSI Patients.
作者信息
Heger Anna, Sator Michael, Walch Katharina, Pietrowski Detlef
机构信息
Psychiatrisches Zentrum Nordbaden, Wiesloch, Germany.
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
出版信息
Geburtshilfe Frauenheilkd. 2018 Jan;78(1):78-82. doi: 10.1055/s-0043-123762. Epub 2018 Jan 22.
INTRODUCTION
Smoking is a serious problem for the health care system. Many of the compounds identified in cigarette smoke have toxic effects on the fertility of both females and males. The purpose of this study was to determine whether smoking affects clinical factors during IVF/ICSI therapy in a single-center reproductive unit.
MATERIAL AND METHODS
In a retrospective study of 200 IVF/ICSI cycles, endometrial thickness and the outcome of IVF/ICSI therapy were analyzed.
RESULTS
Endometrial thickness was significantly lower in smoking patients than in non-smoking patients (10.4 ± 1.5 mm vs. 11.6 ± 1.8 mm). Age was significantly higher in women who failed to conceive. The total dose of gonadotropins administered was significantly lower in pregnant patients and the highest pregnancy rate was achieved with an rFSH protocol. BMI and number of cigarettes smoked did not influence treatment outcomes in this study.
CONCLUSION
We showed that smoking has a negative effect on endometrial thickness on the day of embryo transfer. This may help to further explain the detrimental influence of tobacco smoke on implantation and pregnancy rates during assisted reproduction therapy.
引言
吸烟对医疗保健系统来说是一个严重问题。香烟烟雾中鉴定出的许多化合物对女性和男性的生育能力都有毒性作用。本研究的目的是确定在一个单中心生殖单元中，吸烟是否会影响体外受精/卵胞浆内单精子注射（IVF/ICSI）治疗期间的临床因素。
材料与方法
在一项对200个IVF/ICSI周期的回顾性研究中，分析了子宫内膜厚度和IVF/ICSI治疗的结果。
结果
吸烟患者的子宫内膜厚度显著低于非吸烟患者（10.4±1.5毫米对11.6±1.8毫米）。未受孕女性的年龄显著更高。怀孕患者使用的促性腺激素总剂量显著更低，重组促卵泡素（rFSH）方案的妊娠率最高。在本研究中，体重指数（BMI）和吸烟数量不影响治疗结果。
结论
我们表明，吸烟对胚胎移植当天的子宫内膜厚度有负面影响。这可能有助于进一步解释吸烟对辅助生殖治疗期间着床和妊娠率的有害影响。
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