Fouzi S, Ayadi H, Sellami A, Rekik W K, Guermazi N, Ayadi A, Ayoub A
Service de pneumo-allergologie, CHU Hédi-Chaker, 3029 Sfax, Tunisie.
Ann Endocrinol (Paris). 2009 Apr;70(2):137-40. doi: 10.1016/j.ando.2008.11.001. Epub 2009 Feb 7.
Mucormycosis or zygomycosis is a group of infections caused by filamentous fungi of the mucorales order belonging to the zygomycetes family. They generally appear in patients with uncontrolled diabetes or immunodepression, especially neutropenic immunodepression. Incidence has increased with progress in immunosuppressive therapy and chemotherapy and the absence of the use of antifungal prophylactic agents effective against mucors. We report the case of a diabetic patient presenting with an excavated opacity in the right lung which failed to improve after receiving non-specific antibiotic treatment. Direct examination of the bronchial washing specimen led to the diagnosis of pulmonary mucormycosis. Prognosis depends mainly on early diagnosis, enabling appropriate treatment with amphotericin B. Mortality remains high, around 80%; diagnosis is commonly established post-mortem.
毛霉病或接合菌病是一组由属于接合菌纲毛霉目丝状真菌引起的感染。它们通常出现在糖尿病控制不佳或免疫抑制的患者中，尤其是中性粒细胞减少性免疫抑制患者。随着免疫抑制治疗和化疗的进展以及缺乏有效的抗毛霉抗真菌预防药物的使用，发病率有所增加。我们报告了一例糖尿病患者，其右肺出现一个空洞性混浊，在接受非特异性抗生素治疗后未见改善。对支气管冲洗标本的直接检查导致了肺毛霉病的诊断。预后主要取决于早期诊断，以便能够用两性霉素B进行适当治疗。死亡率仍然很高，约为80%；诊断通常在尸检后确立。
