Philippu A, Kittel E, Schartner P
Contrib Nephrol. 1977;8:195-9. doi: 10.1159/000400630.
In cats anaesthetized with pentobarbital sodium, the posterior hypothalamus was superfused and electrically stimulated with a push-pull cannula. The pressor response to stimulation of this hypothalamic area was inhibited when the hypothalamus was superfused with drugs blocking either alpha-adrenoreceptors (piperoxan, tolazoline), or beta-adrenoreceptors--(+/-)-propranolol, (-)-propranolol, practolol, sotalol, metoprolol. (+)-Propranolol and a concentration of procaine equianaesthetic to propranolol were ineffective. During superfusion with tolazoline in the presence of practolol the inhibition was twice as that when the hypothalamus was superfused with either tolazoline or practolol. In another series of experiments the push-pull cannula was inserted into the anterior hypothalamus. The depressor response to stimulation of this area was inhibited by the hypothalamic superfusion with the alpha-adrenoreceptor blocking drugs phentolamine, tolazoline, piperoxan or yohimbine. Hypothalamic superfusion with phenylephrine abolished the inhibitory effect of phentolamine on the depressor response. The results indicate that adrenoreceptors are present in the hypothalamus and that they are involved in blood pressure changes elicited by hypothalamic stimulation.
在用戊巴比妥钠麻醉的猫中，用推挽式套管对下丘脑后部进行灌流并电刺激。当用阻断α-肾上腺素能受体的药物（哌罗克生、妥拉唑啉）或β-肾上腺素能受体的药物（±）-普萘洛尔、（-）-普萘洛尔、普拉洛尔、索他洛尔、美托洛尔对下丘脑进行灌流时，对该下丘脑区域刺激的升压反应受到抑制。（+）-普萘洛尔和与普萘洛尔等效麻醉浓度的普鲁卡因无效。在普拉洛尔存在下用妥拉唑啉灌流时，抑制作用是下丘脑单独用妥拉唑啉或普拉洛尔灌流时的两倍。在另一系列实验中，将推挽式套管插入下丘脑前部。用α-肾上腺素能受体阻断药物酚妥拉明、妥拉唑啉、哌罗克生或育亨宾对下丘脑进行灌流，可抑制对该区域刺激的降压反应。用去氧肾上腺素对下丘脑进行灌流可消除酚妥拉明对降压反应的抑制作用。结果表明，下丘脑存在肾上腺素能受体，且它们参与下丘脑刺激引起的血压变化。
