Philippu A, Kittel E
Naunyn Schmiedebergs Arch Pharmacol. 1977 Apr;297(3):219-25. doi: 10.1007/BF00509264.
The posterior hypothalamus of cats anaesthetized with pentobarbital sodium was superfused and electrically stimulated with a push-pull cannula. Superfusion of the hypothalamus with (+/-)-, (-)-propranolol, sotalol, practolol or metoprolol caused a concentration-dependent inhibiton of the pressor response to hypothalamic stimulation. (+/-)-Propranolol and a procaine concentration equi-anaesthetic to the concentration of (+/-)- and (-)-propranolol were ineffective. Lower concentrations of propranolol and metoprolol were needed to inhibit the pressor response than of sotalol or practolol. Superfusion with practolol and tolazoline impaired the pressor response to a greater extent than did superfusion with each of the drugs alone. Hypothalamic superfusion with isoproterenol elicited a concentration-dependent enhancement of the rise of blood pressure during electrical stimulation of the hypothalamus. It is concluded that beta-adrenorecptors are present in the posterior hypothalamus and that they are involved in the pressor response elicited by electrical stimulation of the hypothalamus. Propranolol and metoprolol seemed to possess a higher affinity to the beta-receptors of the hypothalamus than sotalol or practolol.
用戊巴比妥钠麻醉的猫，其下丘脑后部通过推挽式插管进行灌流并接受电刺激。用（±）-、（-）-普萘洛尔、索他洛尔、普拉洛尔或美托洛尔灌流下丘脑，会导致对下丘脑刺激的升压反应出现浓度依赖性抑制。（±）-普萘洛尔以及与（±）-和（-）-普萘洛尔浓度等效的麻醉浓度的普鲁卡因无效。抑制升压反应所需的普萘洛尔和美托洛尔浓度低于索他洛尔或普拉洛尔。与单独使用每种药物灌流相比，用普拉洛尔和妥拉唑啉灌流对升压反应的损害更大。用异丙肾上腺素灌流下丘脑会导致在电刺激下丘脑期间血压升高出现浓度依赖性增强。得出的结论是，下丘脑后部存在β-肾上腺素能受体，并且它们参与了下丘脑电刺激引发的升压反应。普萘洛尔和美托洛尔对下丘脑β受体的亲和力似乎高于索他洛尔或普拉洛尔。
