Ahier A, Khayath N, Vicogne J, Dissous C
Inserm U547, Lille, Université Lille 2, Institut Pasteur de Lille, IFR142, Lille, France.
Parasite. 2008 Dec;15(4):573-9. doi: 10.1051/parasite/2008154573.
Very little is known about insulin signalling in schistosomes despite its potential importance in host-parasite molecular dialogue and parasite growth and development. The recent characterization of two insulin receptors (SmIR-1 and SmIR-2) in Schistosoma mansoni has led us to reconsider the question of the potential importance of insulin in host-schistosome interactions. In this work, we demonstrated that insulin could regulate glucose uptake in schistosomes and we investigated the implication of SmIR-1 and SmIR-2 in this process. The possibility that specific inhibitors of SmIR-1 and SmIR-2 tyrosine kinase activities could be developed to target schistosomes is discussed.
尽管胰岛素信号传导在宿主-寄生虫分子对话以及寄生虫生长发育中具有潜在重要性，但关于血吸虫中胰岛素信号传导的了解却非常少。最近对曼氏血吸虫中两种胰岛素受体（SmIR-1和SmIR-2）的表征促使我们重新思考胰岛素在宿主-血吸虫相互作用中潜在重要性的问题。在这项研究中，我们证明胰岛素可以调节血吸虫对葡萄糖的摄取，并研究了SmIR-1和SmIR-2在此过程中的作用。还讨论了开发SmIR-1和SmIR-2酪氨酸激酶活性特异性抑制剂以靶向血吸虫的可能性。
