Chin Kazuo
Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University.
Nihon Rinsho. 2009 Feb;67(2):350-5.
Obstructive sleep apnea (OSA) is characterized by repeated episodes of apnea and hypopnea during sleep. Obesity is the most important risk factor for OSA. From the recent reports, the prevalence of OSA is high. Data have shown that severe OSA (the mean number of apnea and hypopnea episodes per hour slept: AHI > or = 30) is a risk factor for cardiovascular diseases and death. In addition, OSA is widely prevalent in patients with obesity, diabetes, and hypertension which are the major risk factors for cardiovascular disease. Several reports show that sleep duration has significant effects on BMI, mortality and diabetes. It has been reported that leptin and ghrelin, which were the two key hormones in appetite, are elevated in OSA patients. Therefore, it is important to investigate the relationship between OSA, body weight gain and obesity.
阻塞性睡眠呼吸暂停（OSA）的特征是睡眠期间反复出现呼吸暂停和呼吸不足。肥胖是OSA最重要的危险因素。从最近的报告来看，OSA的患病率很高。数据表明，重度OSA（每小时睡眠中呼吸暂停和呼吸不足发作的平均次数：呼吸暂停低通气指数[AHI]≥30）是心血管疾病和死亡的危险因素。此外，OSA在肥胖、糖尿病和高血压患者中广泛存在，而这些疾病是心血管疾病的主要危险因素。几份报告显示，睡眠时间对体重指数、死亡率和糖尿病有显著影响。据报道，食欲的两种关键激素瘦素和胃饥饿素在OSA患者中升高。因此，研究OSA、体重增加和肥胖之间的关系很重要。
