延伸体连接微管蛋白乙酰化与神经元迁移。
Elongator bridges tubulin acetylation and neuronal migration.
作者信息
Wynshaw-Boris Anthony
机构信息
Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, School of Medicine, San Francisco, CA 94143-0794, USA.
出版信息
Cell. 2009 Feb 6;136(3):393-4. doi: 10.1016/j.cell.2009.01.024.
PMID:19203572
Abstract
Neuronal cell migration and maturation are crucial for the development of the mammalian cerebral cortex. In this issue, Creppe et al. (2009) now show that the multisubunit histone acetyltransferase Elongator may regulate migration and branch formation of cortical neurons in the developing mouse brain by acetylating alpha-tubulin.
摘要
神经元细胞迁移和成熟对于哺乳动物大脑皮层的发育至关重要。在本期杂志中，克雷普等人（2009年）现在表明，多亚基组蛋白乙酰转移酶延伸因子可能通过使α-微管蛋白乙酰化来调节发育中小鼠大脑中皮层神经元的迁移和分支形成。
Zotero 插件