Howard Hughes Medical Institute, Cambridge, MA 02139, USA.
Cell. 2010 Jan 8;140(1):30-2. doi: 10.1016/j.cell.2009.12.038.
The microtubule network is crucial for the developing nervous system, and mutations in tubulin-encoding genes disrupt neuronal migration. Tischfield et al. (2010) now report that mutations in the tubulin-encoding gene TUBB3 have a striking impact on microtubule dynamics in neurons, resulting in a diverse set of disease symptoms.
微管网络对于发育中的神经系统至关重要，微管蛋白编码基因的突变会破坏神经元迁移。Tischfield 等人（2010 年）现在报告称，微管蛋白编码基因 TUBB3 的突变对神经元中的微管动力学有显著影响，导致一系列不同的疾病症状。
