肉桂提取物通过调节血管生成和CD8 + T细胞的效应功能来抑制肿瘤进展。
Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.
作者信息
Kwon Ho-Keun, Jeon Won Kyung, Hwang Ji-Sun, Lee Choong-Gu, So Jae-Seon, Park Jin-A, Ko Byoung Seob, Im Sin-Hyeog
机构信息
Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea.
Department of Herbal Resources Research and Quality Control Team, Korea Institute of Oriental Medicine, 305-811 Daejeon, Republic of Korea.
出版信息
Cancer Lett. 2009 Jun 18;278(2):174-182. doi: 10.1016/j.canlet.2009.01.015. Epub 2009 Feb 8.
Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.
肉桂是使用最广泛的草药之一，具有多种生物活性作用。然而，关于肉桂潜在的抗肿瘤作用，鲜有证据报道。在体外和体内系统中，肉桂处理不仅在黑色素瘤细胞系中，而且在实验性黑色素瘤模型中，均强烈抑制促血管生成因子的表达以及肿瘤进展的主要调节因子。此外，肉桂处理通过提高细胞溶解分子水平及其细胞毒性活性，增强了CD8(+) T细胞的抗肿瘤活性。总之，肉桂提取物有潜力成为肿瘤治疗的替代药物。
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