Khedkar Shubrata, Ahmad Khan Minhaj
Department of Biochemistry, Lovely Professional University, Jalandhar 144411, Punjab, India.
Evid Based Complement Alternat Med. 2023 May 11;2023:5467342. doi: 10.1155/2023/5467342. eCollection 2023.
Cinnamon ( spp.; family Lauraceae), a plant widely used as a spice and flavoring agent and in the perfume industry, has high therapeutic value. However, the components and chemical properties of cinnamon extracts vary depending on the part of the plant, the method, and the solvent used for extraction. Green extraction methods using safe and green solvents have gained increased interest in recent years. Water is an environmentally friendly and safe green solvent widely used for preparing cinnamon extracts. This review focuses on the various preparation techniques for the aqueous extract of cinnamon, its major bioactive components, and their beneficial roles in different pathological conditions, specifically cancer and inflammation. The aqueous extract of cinnamon contains several bioactive compounds, such as cinnamaldehyde, cinnamic acid, and polyphenols, and exerts anticancer and anti-inflammatory properties by altering key apoptotic and angiogenic factors. The whole extract is a better anticancer and anti-inflammatory agent than the purified fractions, indicating a synergistic effect between various components. Studies have indicated that aqueous cinnamon extract has immense therapeutic potential, and to better understand its synergistic effects, extensive characterization of the aqueous extract and its potential to be used with other therapies should be explored.
肉桂（樟属；樟科）是一种广泛用作香料、调味剂以及应用于香水行业的植物，具有很高的治疗价值。然而，肉桂提取物的成分和化学性质会因植物部位、提取方法以及所用溶剂的不同而有所差异。近年来，使用安全绿色溶剂的绿色提取方法越来越受到关注。水是一种环境友好且安全的绿色溶剂，广泛用于制备肉桂提取物。本综述重点关注肉桂水提取物的各种制备技术、其主要生物活性成分以及它们在不同病理状况下，特别是癌症和炎症中的有益作用。肉桂水提取物含有多种生物活性化合物，如肉桂醛、肉桂酸和多酚，并通过改变关键的凋亡和血管生成因子发挥抗癌和抗炎特性。整个提取物作为抗癌和抗炎剂比纯化后的组分效果更好，这表明各种成分之间存在协同作用。研究表明，肉桂水提取物具有巨大的治疗潜力，为了更好地理解其协同作用，应探索对水提取物进行广泛表征及其与其他疗法联合使用的潜力。
