Lin Meng Meng, Kim Do Kyung, El Haj Alicia J, Dobson Jon
Institute for Science and Technology in Medicine, Keele University, ST4 7QB, UK.
IEEE Trans Nanobioscience. 2008 Dec;7(4):298-305. doi: 10.1109/TNB.2008.2011864.
Superparamagnetic iron oxide nanoparticles (SPIONs) have attract a great deal of interest in biomedical research and clinical applications over the past decades. Taking advantage the fact that SPIONs only exhibit magnetic properties in the presence of an applied magnetic field, they have been used in both in vitro magnetic separation and in vivo applications such as hyperthermia (HT), magnetic drug targeting (MDT), magnetic resonance imaging (MRI), gene delivery (GD) and nanomedicine. Successful applications of SPIONs rely on precise control of the particle's shape, size, and size distribution and several synthetic routes for preparing SPIONs have been explored. Tailored surface properties specifically designed for cell targeting are often required, although the generic strategy involves creating biocompatible polymeric or non-polymeric coating and subsequent conjugation of bioactive molecules. In this review article, synthetic routes, surface modification and functionaliztion of SPIONs, as well as the major biomedical applications are summarized, with emphasis on in vivo applications.
在过去几十年中，超顺磁性氧化铁纳米颗粒（SPIONs）在生物医学研究和临床应用中引起了广泛关注。利用SPIONs仅在施加磁场时才表现出磁性这一事实，它们已被用于体外磁分离以及诸如热疗（HT）、磁性药物靶向（MDT）、磁共振成像（MRI）、基因递送（GD）和纳米医学等体内应用。SPIONs的成功应用依赖于对颗粒形状、尺寸和尺寸分布的精确控制，并且已经探索了几种制备SPIONs的合成路线。尽管通用策略包括创建生物相容性聚合物或非聚合物涂层以及随后生物活性分子的共轭，但通常需要专门为细胞靶向设计的定制表面性质。在这篇综述文章中，总结了SPIONs的合成路线、表面修饰和功能化以及主要的生物医学应用，重点是体内应用。
