超顺磁性氧化铁纳米粒子（SPIONs）在体外和体内癌症纳米治疗中的最新进展。
Recent advances in superparamagnetic iron oxide nanoparticles (SPIONs) for in vitro and in vivo cancer nanotheranostics.
机构信息
Nanomaterials Lab, Department of Mechanical Engineering, Shiv Nadar University, Uttar Pradesh 201314, India.
Nanomaterials Lab, Department of Mechanical Engineering, Shiv Nadar University, Uttar Pradesh 201314, India.
出版信息
Int J Pharm. 2015 Dec 30;496(2):191-218. doi: 10.1016/j.ijpharm.2015.10.058. Epub 2015 Oct 28.
Recently superparamagnetic iron oxide nanoparticles (SPIONs) have been extensively used in cancer therapy and diagnosis (theranostics) via magnetic targeting, magnetic resonance imaging, etc. due to their remarkable magnetic properties, chemical stability, and biocompatibility. However, the magnetic properties of SPIONs are influenced by various physicochemical and synthesis parameters. So, this review mainly focuses on the influence of spin canting effects, introduced by the variations in size, shape, and organic/inorganic surface coatings, on the magnetic properties of SPIONs. This review also describes the several predominant chemical synthesis procedures and role of the synthesis parameters for monitoring the size, shape, crystallinity and composition of the SPIONs. Moreover, this review discusses about the latest developments of the inorganic materials and organic polymers for encapsulation of the SPIONs. Finally, the most recent advancements of the SPIONs and their nanopackages in combination with other imaging/therapeutic agents have been comprehensively discussed for their effective usage as in vitro and in vivo theranostic agents in cancer treatments.
最近，超顺磁性氧化铁纳米粒子（SPIONs）由于其显著的磁性能、化学稳定性和生物相容性，已被广泛应用于癌症的治疗和诊断（治疗学），如通过磁靶向、磁共振成像等。然而，SPIONs 的磁性受到各种物理化学和合成参数的影响。因此，本综述主要关注通过尺寸、形状和有机/无机表面涂层的变化引入的自旋倾斜效应对 SPIONs 磁性的影响。本综述还描述了几种主要的化学合成方法以及合成参数的作用，用于监测 SPIONs 的尺寸、形状、结晶度和组成。此外，本综述还讨论了用于封装 SPIONs 的无机材料和有机聚合物的最新进展。最后，综合讨论了 SPIONs 及其纳米封装与其他成像/治疗剂的联合应用，以作为癌症治疗中体外和体内治疗学的有效试剂。
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