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High-fat diet, obesity and prostate disease: the ATX-LPA axis?

作者信息

Kulkarni Prakash, Getzenberg Robert H

机构信息

James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

出版信息

Nat Clin Pract Urol. 2009 Mar;6(3):128-31. doi: 10.1038/ncpuro1311. Epub 2009 Feb 10.

DOI:10.1038/ncpuro1311
PMID:19204739
Abstract
摘要

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High-fat diet, obesity and prostate disease: the ATX-LPA axis?高脂饮食、肥胖与前列腺疾病：自噬相关蛋白-溶血磷脂酸轴？
Nat Clin Pract Urol. 2009 Mar;6(3):128-31. doi: 10.1038/ncpuro1311. Epub 2009 Feb 10.
2
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Lipid generation and signaling in ovarian cancer.卵巢癌中的脂质生成与信号传导。
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4
Lysophosphatidic acids, cyclic phosphatidic acids and autotaxin as promising targets in therapies of cancer and other diseases.溶血磷脂酸、环磷酸酯酸和自分泌运动因子作为癌症及其他疾病治疗中颇具前景的靶点。
Acta Biochim Pol. 2008;55(2):227-40. Epub 2008 Jun 14.
5
Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.自分泌运动因子通过产生溶血磷脂酸来稳定血管，是胚胎血管系统所必需的。
J Biol Chem. 2006 Sep 1;281(35):25822-30. doi: 10.1074/jbc.M605142200. Epub 2006 Jul 6.
6
Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia.自分泌运动因子和溶血磷脂酸通过将肌动蛋白修饰蛋白绒毛蛋白重新分布到正在形成的片状伪足，来刺激肠道细胞运动。
Exp Cell Res. 2008 Feb 1;314(3):530-42. doi: 10.1016/j.yexcr.2007.10.028. Epub 2007 Nov 12.
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Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression.溶血磷脂酸的产生和作用：乳腺癌起始和进展中的关键新角色。
Br J Cancer. 2010 Mar 16;102(6):941-6. doi: 10.1038/sj.bjc.6605588.
8
[Clinical introduction of lysophosphatidic acid and autotaxin assays].[溶血磷脂酸和自分泌运动因子检测的临床介绍]
Rinsho Byori. 2010 Jun;58(6):631-5.
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Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis.自分泌运动因子可保护MCF-7乳腺癌细胞和MDA-MB-435黑色素瘤细胞免受紫杉醇诱导的凋亡。
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Role of lysophosphatidic acid in the regulation of uterine leiomyoma cell proliferation by phospholipase D and autotaxin.溶血磷脂酸在磷脂酶D和自分泌运动因子调节子宫平滑肌瘤细胞增殖中的作用
J Lipid Res. 2008 Feb;49(2):295-307. doi: 10.1194/jlr.M700171-JLR200. Epub 2007 Nov 16.

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本文引用的文献

1
Gene expression profiles of lysophosphatidic acid-related molecules in the prostate: relevance to prostate cancer and benign hyperplasia.前列腺中溶血磷脂酸相关分子的基因表达谱：与前列腺癌和良性增生的相关性。
Prostate. 2009 Feb 15;69(3):283-92. doi: 10.1002/pros.20879.
2
Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome.疾病的发育起源与染色质结构的决定因素：母体饮食可改变灵长类胎儿的表观基因组。
J Mol Endocrinol. 2008 Aug;41(2):91-102. doi: 10.1677/JME-08-0025. Epub 2008 May 30.
3
Prostate growth and inflammation.
Regulation of CD8 T-cell signaling, metabolism, and cytotoxic activity by extracellular lysophosphatidic acid.
细胞外溶血磷脂酸对 CD8 T 细胞信号转导、代谢和细胞毒性活性的调节。
Immunol Rev. 2023 Aug;317(1):203-222. doi: 10.1111/imr.13208. Epub 2023 Apr 25.
4
Dietary Carcinogens and DNA Adducts in Prostate Cancer.膳食中的致癌物质与前列腺癌中的 DNA 加合物。
Adv Exp Med Biol. 2019;1210:29-55. doi: 10.1007/978-3-030-32656-2_2.
5
Inflammatory Signaling Involved in High-Fat Diet Induced Prostate Diseases.高脂饮食诱导的前列腺疾病中涉及的炎症信号传导
J Urol Res. 2015 Jan 1;2(1). Epub 2015 Jan 12.
6
Lysophosphatidic acid (LPA) signaling in human and ruminant reproductive tract.溶血磷脂酸（LPA）在人类和反刍动物生殖道中的信号传导
Mediators Inflamm. 2014;2014:649702. doi: 10.1155/2014/649702. Epub 2014 Mar 12.
7
Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness.Cyr61 受 cAMP 依赖性蛋白激酶调节，其血清水平与前列腺癌侵袭性相关。
Prostate. 2012 Jun 15;72(9):966-76. doi: 10.1002/pros.21501. Epub 2011 Oct 24.
8
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.自分泌运动因子和酰基甘油激酶在前列腺癌中的表达：与癌症发生发展的关联
Cancer Sci. 2009 Sep;100(9):1631-8. doi: 10.1111/j.1349-7006.2009.01234.x. Epub 2009 May 31.
前列腺增生与炎症。
J Steroid Biochem Mol Biol. 2008 Feb;108(3-5):254-60. doi: 10.1016/j.jsbmb.2007.09.013. Epub 2007 Sep 7.
4
Activatory properties of lysophosphatidic acid on human THP-1 cells.溶血磷脂酸对人THP-1细胞的激活特性。
Inflammation. 2007 Oct;30(5):167-77. doi: 10.1007/s10753-007-9034-2.
5
Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha.溶血磷脂酸通过激活LPA(1)、p42和p38α诱导前列腺癌PC3细胞迁移。
Biochim Biophys Acta. 2007 Jul;1771(7):883-92. doi: 10.1016/j.bbalip.2007.04.010. Epub 2007 Apr 24.
6
Regulation and biological activities of the autotaxin-LPA axis.自分泌运动因子-溶血磷脂酸轴的调节及生物学活性
Prog Lipid Res. 2007 Mar;46(2):145-60. doi: 10.1016/j.plipres.2007.02.001. Epub 2007 Mar 16.
7
Risk factors for prostate cancer incidence and progression in the health professionals follow-up study.健康专业人员随访研究中前列腺癌发病和进展的风险因素。
Int J Cancer. 2007 Oct 1;121(7):1571-8. doi: 10.1002/ijc.22788.
8
The obesity-cancer link: lessons learned from a fatless mouse.肥胖与癌症的关联：从无脂肪小鼠身上获得的经验教训。
Cancer Res. 2007 Mar 15;67(6):2391-3. doi: 10.1158/0008-5472.CAN-06-4237.
9
[Secretion and role of autotaxin and lysophosphatidic acid in adipose tissue].[自分泌运动因子和溶血磷脂酸在脂肪组织中的分泌及作用]
J Soc Biol. 2006;200(1):77-81. doi: 10.1051/jbio:2006010.
10
Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer.蜘蛛与螃蟹：溶血磷脂及其代谢途径作为癌症治疗靶点的出现
Clin Cancer Res. 2006 Nov 15;12(22):6598-602. doi: 10.1158/1078-0432.CCR-06-1721.