Kim Jong-Hoon, Byun Hee-Jung
Department of Psychiatry, Gil Medical Center, Gachon University of Medicine and Science, Incheon, Korea.
Hum Psychopharmacol. 2009 Mar;24(2):129-33. doi: 10.1002/hup.1009.
The purpose of the present study was to examine the relationship between drug-induced parkinsonism (DIP) and subjective non-motor cognitive impairments in schizophrenia by performing comprehensive assessments of extrapyramidal side effects (EPS) and the subjective cognitive-perceptual functioning.
Ninety-one outpatients with schizophrenia were evaluated for DIP and other EPS. Subjective cognitive-perceptual dysfunction was comprehensively assessed using the Frankfurt Complaint Questionnaire (FCQ). To examine the association between DIP and non-motor cognitive-perceptual dysfunction, Pearson's partial correlation analysis was performed between the FCQ scores and the severity of DIP, controlling for relevant variables.
The analysis revealed that the severity of DIP had a significant correlation with the total FCQ score (p < 0.05). In phenomenological subscales, the severity of DIP showed significant correlations with "deterioration of discrimination," "psychomotor disorder," "perceptual disorder," "cognitive floating," and "automatic behavior disorder" (p < 0.05).
The results of our study suggest that DIP is significantly associated with a wide range of subjective non-motor cognitive impairments. Clinicians should be careful of the appearance of DIP and the associated non-motor cognitive-perceptual symptoms, which may cause considerable distress and reduce the quality of life in an already vulnerable group of patients.
本研究旨在通过对外锥体外系副作用（EPS）和主观认知-感知功能进行全面评估，探讨药物性帕金森综合征（DIP）与精神分裂症患者主观非运动性认知障碍之间的关系。
对91例精神分裂症门诊患者进行DIP及其他EPS评估。使用法兰克福主诉问卷（FCQ）全面评估主观认知-感知功能障碍。为检验DIP与非运动性认知-感知功能障碍之间的关联，在控制相关变量的情况下，对FCQ得分与DIP严重程度进行Pearson偏相关分析。
分析显示，DIP严重程度与FCQ总分显著相关（p<0.05）。在现象学子量表中，DIP严重程度与“辨别能力下降”“精神运动障碍”“感知障碍”“认知飘浮”及“自动行为障碍”显著相关（p<0.05）。
我们的研究结果表明，DIP与广泛的主观非运动性认知障碍显著相关。临床医生应注意DIP及其相关的非运动性认知-感知症状的出现，这些可能会给本就脆弱的患者群体带来相当大的痛苦并降低其生活质量。
