Kim Jong-Hoon, Kim Min-Jung
Department of Psychiatry, Gil Medical Center, Gachon University of Medicine and Science, Incheon, South Korea.
Clin Neuropharmacol. 2009 Sep-Oct;32(5):250-3. doi: 10.1097/WNF.0b013e3181a5d08c.
The purpose of the present study was to examine the association of adverse drug effects with subjective well-being in patients with schizophrenia receiving stable doses of risperidone.
Thirty outpatients with schizophrenia receiving stable doses of risperidone were comprehensively evaluated for psychopathology, subjective well-being, and adverse drug effects. Subjective well-being was assessed using the Subjective Well-being Under Neuroleptics Scale (SWN). Adverse drug effects were evaluated using the Liverpool University Neuroleptic Side Effect Rating Scale (LUNSERS) and the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS).
In correlation analysis controlling for relevant variables, the SWN score had significant negative correlations with the following subscale scores of the LUNSERS: extrapyramidal side effect (EPS) (r = -0.54, P < 0.01), akathisia (r = -0.46, P < 0.05), and autonomic adverse effect (r = -0.44, P < 0.05). The SWN score also had a significant negative correlation with the global severity of EPS as measured by the DIEPSS (r = -0.44, P < 0.05).
The results of our study suggest that adverse effects, particularly EPS and akathisia, are significantly associated with subjective well-being, implying the necessity to develop rational strategies to control these variables effectively. The results also suggest that EPS and akathisia continue to be major adverse effects associated with a low level of subjective well-being in patients receiving risperidone. Further studies are required to investigate the multidimensional factors associated with subjective well-being in patients receiving atypical antipsychotics and to determine their relative contributions.
本研究旨在探讨接受稳定剂量利培酮治疗的精神分裂症患者药物不良反应与主观幸福感之间的关联。
对30名接受稳定剂量利培酮治疗的精神分裂症门诊患者进行了心理病理学、主观幸福感和药物不良反应的综合评估。使用抗精神病药物治疗下的主观幸福感量表（SWN）评估主观幸福感。使用利物浦大学抗精神病药物副作用评定量表（LUNSERS）和药物性锥体外系症状量表（DIEPSS）评估药物不良反应。
在控制相关变量的相关性分析中，SWN得分与LUNSERS的以下子量表得分呈显著负相关：锥体外系副作用（EPS）（r = -0.54，P < 0.01）、静坐不能（r = -0.46，P < 0.05）和自主神经不良反应（r = -0.44，P < 0.05）。SWN得分与DIEPSS测量的EPS总体严重程度也呈显著负相关（r = -0.44，P < 0.05）。
我们的研究结果表明，不良反应，尤其是EPS和静坐不能，与主观幸福感显著相关，这意味着有必要制定合理策略来有效控制这些变量。结果还表明，EPS和静坐不能仍然是接受利培酮治疗患者主观幸福感水平较低的主要不良反应。需要进一步研究调查接受非典型抗精神病药物治疗患者主观幸福感的多维度因素，并确定它们的相对贡献。
