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复发缓解型多发性硬化症的前庭表现:一项对30例患者的研究。

Vestibular findings in relapsing, remitting multiple sclerosis: a study of thirty patients.

作者信息

Zeigelboim Bianca S, Arruda Walter O, Mangabeira-Albernaz Pedro L, Iório Maria Cecília M, Jurkiewicz Ari L, Martins-Bassetto Jackeline, Klagenberg Karlin F

机构信息

Department of Otoneurology, Universidade Tuiuti do Paraná, Curitiba, Brazil.

出版信息

Int Tinnitus J. 2008;14(2):139-45.

Abstract

Our objective was to describe vestibular abnormalities in patients with relapsing and remitting multiple sclerosis. Thirty patients (6 men and 24 women) between 27 and 64 years of age underwent neurological and otolaryngological examinations, complete anamnesis, and electronystagmography. Patients with psychological or oculomotor paresis (or both), internuclear ophthalmoparesis, severe visual disturbances, or locomotion restrictions were excluded. The difference-of-proportion test was used to compare affected patients with controls, with a significance level of 5%. Vestibular alterations were found in 26 (86%) of the evaluated patients, from which 25 presented peripheral etiology and only 1 presented a problem of central origin. There was a prevalence of bilateral peripheral irritative vestibulopathy (20%), followed by bilateral peripheral deficit vestibulopathy (20%) and left peripheral deficit vestibulopathy (17%). The high incidence of vestibular disorders observed in this study indicates that this population might benefit from specific rehabilitation programs. Studies with larger samples are still required and may contribute to the understanding of this pathology.

摘要

我们的目标是描述复发缓解型多发性硬化症患者的前庭异常情况。30例年龄在27岁至64岁之间的患者(6名男性和24名女性)接受了神经科和耳鼻喉科检查、全面问诊以及眼震电图检查。排除了患有心理性或动眼神经麻痹(或两者皆有)、核间性眼肌麻痹、严重视力障碍或行动受限的患者。采用比例差异检验来比较患病患者与对照组,显著性水平为5%。在26例(86%)接受评估的患者中发现了前庭改变,其中25例为外周病因,仅有1例为中枢性病因。双侧外周刺激性前庭病的患病率为20%,其次是双侧外周缺损性前庭病(20%)和左侧外周缺损性前庭病(17%)。本研究中观察到的前庭疾病高发病率表明,这一人群可能会从特定的康复计划中受益。仍需要进行更大样本量的研究,这可能有助于对这种病理状况的理解。

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