Krzesiek Elzbieta, Pytrus Tomasz, Kosmowska Agnieszka, Iwańczak Barbara
Akademia Medyczna we Wrocławiu, II Katedra i Klinika Pediatrii, Gastroenterologii i Zywienia.
Pol Merkur Lekarski. 2008 Dec;25(150):455-9.
In patients with inflammatory bowel diseases, in inflamed alimentary tract mucosa the number of phagocytic cells (macrophages, neutrophils, monocytes), which are the source of reactive oxygen forms, is increased as compared with healthy mucosa. The intensity of the inflammation correlates with the production of free oxygen radicals.
To demonstration of connection between inflammatory process activity in ulcerative colitis and Crohn's disease and carbonyl groups level.
The study comprised 63 children hospitalized in The 2nd Chair and Department of Pediatrics, Gastroenterology and Feeding of Children. In 50 children inflammatory bowel diseases were diagnosed, including 26 with ulcerative colitis, 17 with Crohn's disease and 7 with indeterminate colitis; 13 patients composed control group. In all patients the amount of carbonyl groups in serum proteins, erythrocytes sedimentation rate, C-reactive protein, seromucoid, cytoplasmic and perinuclear types of antinuclear antibodies against neutrophils cytoplasm, were determined.
Among the children with inflammatory bowel diseases 58% had an increased content of carbonyl groups in the serum as compared to 7.7% in control group. In patient with inflammatory bowel diseases an improper concentration of carbonyl groups was more frequently observed in ulcerative colitis (69.2%) and this frequency increased along with activity of the disease.
The content of carbonyl groups in the serum in patients with inflammatory bowel diseases increases with activity of inflammatory process and other selected markers of inflammation. There is a need to answer the question whether free radical scavengers can influence the treatment course in patients with inflammatory bowel diseases and whether they should be used routinely.
在炎症性肠病患者中，与健康黏膜相比，发炎的消化道黏膜中作为活性氧形式来源的吞噬细胞（巨噬细胞、中性粒细胞、单核细胞）数量增加。炎症强度与游离氧自由基的产生相关。
证明溃疡性结肠炎和克罗恩病炎症过程活动与羰基水平之间的联系。
该研究纳入了在第二儿科、胃肠病学与儿童喂养科住院的63名儿童。50名儿童被诊断为炎症性肠病，其中26例为溃疡性结肠炎，17例为克罗恩病，7例为不确定性结肠炎；13例患者组成对照组。测定了所有患者血清蛋白中的羰基含量、红细胞沉降率、C反应蛋白、血清类黏蛋白、抗中性粒细胞胞质抗体的胞质型和核周型。
炎症性肠病患儿中，58%的患者血清羰基含量增加，而对照组为7.7%。在炎症性肠病患者中，溃疡性结肠炎患者更常出现羰基浓度异常（69.2%），且该频率随疾病活动度增加。
炎症性肠病患者血清中的羰基含量随炎症过程活动度及其他选定的炎症标志物增加。有必要回答自由基清除剂是否会影响炎症性肠病患者的治疗过程以及是否应常规使用的问题。
