Starska Katarzyna, Głowacka Ewa, Łukomski Marek, Lewy-Trenda Iwona, Józefowicz-Korczyńska Magdalena, Durko Marcin, Lewkowicz Przemysław
Katedra Otolaryngologii UM w Łodzi.
Otolaryngol Pol. 2008;62(6):674-9. doi: 10.1016/S0030-6657(08)70338-X.
Results of studies analyzing the role of immunocompetent cells in tumor environment and whole peripheral blood indicate their responsibility for aggressiveness of neoplasm, prognosis and therapeutic effect. Atcivation of lymhocytes T is connected with expression the markers (antigens) on their surface. The aim of this study was the analysis of activation antigens expression on lymphocytes T in patients with laryngeal carcinoma and the connection with clinicomorphological features.
Analysis of activation antigens expression CD69, CD71 and CD25, CD26, HLA/DR on lymphocytes T CD4+ i CD8+ in 33 patients with squamous cell carcinoma of the larynx was performed. Flow cytometry-based analysis of activation antigens in T cell cultures with and without PHA stimulation was used. The connection of these molecules and clinicomorphological features was examined (pT, pN, G, Anneroth, Batsakis and Lunas' classification).
The significant correlation between chosen markers of activation and tumor features were noted: pT with HLA/DR/CD4, CD69CD8, CD71CD8, pN with CD26CD8, G with CD25CD8, CD71CD8, ABL score with CD25CD4.
Our data indicated the connetion of immunocompetent cell activity and spread of neoplasm in patients with laryngeal carcinoma.
分析免疫活性细胞在肿瘤环境和全外周血中的作用的研究结果表明，它们与肿瘤的侵袭性、预后和治疗效果有关。T淋巴细胞的激活与它们表面标志物（抗原）的表达有关。本研究的目的是分析喉癌患者T淋巴细胞上激活抗原的表达及其与临床形态学特征的关系。
对33例喉鳞状细胞癌患者的CD4+和CD8+T淋巴细胞上激活抗原CD69、CD71和CD25、CD26、HLA/DR的表达进行分析。采用基于流式细胞术的方法分析有无PHA刺激的T细胞培养物中的激活抗原。检查这些分子与临床形态学特征（pT、pN、G、安纳罗思、巴塔基斯和卢纳斯分类）之间的关系。
观察到所选激活标志物与肿瘤特征之间存在显著相关性：pT与HLA/DR/CD4、CD69CD8、CD71CD8相关，pN与CD26CD8相关，G与CD25CD8、CD71CD8相关，ABL评分与CD25CD4相关。
我们的数据表明喉癌患者免疫活性细胞活性与肿瘤扩散之间存在关联。
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