Akinola O B, Oladosu O S, Dosumu O O
Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Afr J Med Med Sci. 2007 Jun;36(2):137-40.
Reactive oxygen species (ROS), among other factors, have been implicated in the aetiology of male infertility. Thus, the roles of antioxidants at improving sperm production and quality are being investigated. The present study was designed to assess the effect of the ethanol extract of fresh leaves of Psidium guajava Linn. on the sperm parameters of healthy male Wistar rats. A total of 18 rats, weighing between 108-124 g, were divided into 3 groups of 6 animals each. Animals in groups 1 and 2 were administered 250 mg/kg/d and 500 mg/kg/d of guava leaf extract (GLE) orally for 53 days respectively. Group 3 animals received normal saline. Sperm count increased from 56.2+/-0.3 (x10(6)) in the control to 57.1+/-0.2 (x10(6)) in group 1 animals, and from 56.2+/-0.3 (x10(6)) in the control to 72.3+/-0.4 (x10(6)) in group 2 animals. Similarly, dose-dependent increases in the percentages of motile spermatozoa were observed in GLE-treated animals compared to the control group. These findings suggest that the extracts of the leaves of Psidium guajava Linn. possess beneficial effects on sperm production and quality, and may thus improve the sperm parameters of infertile males with oligospermia and nonobstructive azoospermia.
除其他因素外，活性氧（ROS）与男性不育的病因有关。因此，正在研究抗氧化剂在改善精子生成和质量方面的作用。本研究旨在评估番石榴新鲜叶片乙醇提取物对健康雄性Wistar大鼠精子参数的影响。总共18只体重在108 - 124克之间的大鼠被分为3组，每组6只动物。第1组和第2组动物分别口服250毫克/千克/天和500毫克/千克/天的番石榴叶提取物（GLE），持续53天。第3组动物接受生理盐水。精子计数从对照组的56.2±0.3（×10⁶）增加到第1组动物的57.1±0.2（×10⁶），从对照组的56.2±0.3（×10⁶）增加到第2组动物的72.3±0.4（×10⁶）。同样，与对照组相比，在GLE处理的动物中观察到活动精子百分比呈剂量依赖性增加。这些发现表明，番石榴新鲜叶片提取物对精子生成和质量具有有益作用，因此可能改善少精子症和非梗阻性无精子症不育男性的精子参数。
