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特发性CD4+ T淋巴细胞减少症

Idiopathic CD4+ T-cell lymphocytopenia.

作者信息

Mukherjee Aparna, Lodha Rakesh, Kabra S K

机构信息

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Indian J Pediatr. 2009 Apr;76(4):430-2. doi: 10.1007/s12098-009-0002-8. Epub 2009 Feb 10.

DOI:10.1007/s12098-009-0002-8
PMID:19205641
Abstract

Idiopathic CD4+ T lymphocytopenia (ICL) is an unusual immune defect in which there is an unexplained deficit of CD4+ T cells, leading to serious opportunistic infections. In view of the rarity of this clinical entity, we report two cases of ICL who presented with low CD4+ count or percentage and various opportunistic infections like candida, cytomegalovirus, Mycobacterium tuberculosis.

摘要

特发性CD4⁺T淋巴细胞减少症（ICL）是一种罕见的免疫缺陷病，其特征为CD4⁺T细胞数量不明原因减少，可导致严重的机会性感染。鉴于该临床病症较为罕见，我们报告两例ICL患者，其CD4⁺细胞计数或百分比偏低，并伴有念珠菌、巨细胞病毒、结核分枝杆菌等多种机会性感染。

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本文引用的文献

1
Detection of CD4(+) T-cell antibodies in a patient with idiopathic CD4 T lymphocytopenia and cryptococcal meningitis.一名患有特发性CD4 T淋巴细胞减少症和隐球菌性脑膜炎患者体内CD4(+) T细胞抗体的检测
Br J Haematol. 2007 Oct;139(1):133-7. doi: 10.1111/j.1365-2141.2007.06781.x.
2
Disseminated cutaneous Kaposi sarcoma and progressive multifocal leukoencephalopathy in a patient with idiopathic CD4+ T lymphocytopenia.
Arch Dermatol. 2007 May;143(5):673-5. doi: 10.1001/archderm.143.5.673.
3
Epstein - Barr virus-positive malignant lymphoma of salivary gland developing in an infant with selective depletion of CD4-positive lymphocytes.一名患有CD4阳性淋巴细胞选择性耗竭的婴儿发生的唾液腺爱泼斯坦-巴尔病毒阳性恶性淋巴瘤。
特发性 T 淋巴细胞减少症中 T 细胞对鞘氨醇 1-磷酸和趋化因子 CCL21 的趋化作用缺陷。
J Clin Immunol. 2011 Oct;31(5):744-51. doi: 10.1007/s10875-011-9554-2. Epub 2011 Jun 14.
Leuk Lymphoma. 2007 Jan;48(1):183-6. doi: 10.1080/10428190600909537.
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Idiopathic CD4+ lymphocytopenia and Sjogren syndrome.特发性CD4+淋巴细胞减少症与干燥综合征。
Arch Ophthalmol. 2005 Jul;123(7):1012. doi: 10.1001/archopht.123.7.1012-a.
5
Idiopathic CD4+ lymphocytopenia may be due to decreased bone marrow clonogenic capability.特发性CD4+淋巴细胞减少症可能是由于骨髓克隆能力下降所致。
Int Arch Allergy Immunol. 2005 Apr;136(4):379-84. doi: 10.1159/000084258. Epub 2005 Mar 2.
6
Idiopathic CD4+ lymphocytopenia and juvenile laryngeal papillomatosis.特发性CD4 +淋巴细胞减少症与青少年喉乳头状瘤病
Pediatr Pulmonol. 2005 Mar;39(3):281-3. doi: 10.1002/ppul.20173.
7
Idiopathic CD4+ T-lymphocytopenia in a boy with Down syndrome. Report of a patient and a review of the literature.
Eur J Pediatr. 2004 Feb;163(2):122-3. doi: 10.1007/s00431-003-1375-8. Epub 2003 Dec 19.
8
Lymphocyte diversity in a 9-year-old boy with idiopathic CD4+ T cell lymphocytopenia.
Int Arch Allergy Immunol. 2001 May;125(1):80-5. doi: 10.1159/000053800.
9
Overexpression of Fas/CD95 and Fas-induced apoptosis in a patient with idiopathic CD4+ T lymphocytopenia.
Clin Infect Dis. 1999 May;28(5):1012-6. doi: 10.1086/514739.
10
Treatment of idiopathic CD4 T lymphocytopenia with IL-2.用白细胞介素-2治疗特发性CD4 T淋巴细胞减少症。
Clin Exp Immunol. 1999 May;116(2):322-5. doi: 10.1046/j.1365-2249.1999.00886.x.