Hashimoto Kenji, Mayahara Hiroshi, Takashima Atsuo, Nakajima Takako Eguchi, Kato Ken, Hamaguchi Tetsuya, Ito Yoshinori, Yamada Yasuhide, Kagami Yoshikazu, Itami Jun, Shimada Yasuhiro
Gastrointestinal Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
J Cancer Res Clin Oncol. 2009 Aug;135(8):1117-23. doi: 10.1007/s00432-009-0553-0. Epub 2009 Feb 10.
To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer.
Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were 40 Gy (range 2-50 Gy) and 2.5 Gy (range 1.8-3 Gy).
The treatment success rate was 68.4%. By using a tumor alpha/beta ratio of 10, biological effective dose of 50 Gy(10) or more was significantly correlated with treatment success (P = 0.040). The median event-free survival was 1.5 months after RT and the median overall survival from starting RT was 3.4 months. Grade 3 nausea and anorexia were recorded in 1 and 3 patients, respectively.
Palliative RT was effective for hemostasis in patients with gastric cancer bleeding with minor adverse events.
阐明姑息性放疗（RT）的毒性及其对不可切除胃癌出血的疗效。
回顾了19例因不可切除胃癌出血接受姑息性RT治疗患者的临床资料。总剂量中位数和每次分割剂量分别为40 Gy（范围2 - 50 Gy）和2.5 Gy（范围1.8 - 3 Gy）。
治疗成功率为68.4%。采用肿瘤α/β比值为10时，生物等效剂量50 Gy(10)及以上与治疗成功显著相关（P = 0.040）。放疗后无事件生存期中位数为1.5个月，从开始放疗起的总生存期中位数为3.4个月。分别有1例和3例患者出现3级恶心和厌食。
姑息性放疗对胃癌出血患者止血有效，且不良事件轻微。
