Becker Nikolaus, Fortuny Joan, Alvaro Tomas, Nieters Alexandra, Maynadié Marc, Foretova Lenka, Staines Anthony, Brennan Paul, Boffetta Paolo, Cocco Pier Luigi, de Sanjose Silvia
Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
J Cancer Res Clin Oncol. 2009 Aug;135(8):1099-107. doi: 10.1007/s00432-009-0551-2. Epub 2009 Feb 11.
Lymphomas are a heterogeneous group of immune-cell malignancies. Immunology-related conditions are among the few factors for which consistent evidence exists relating them to lymphoma risk.
We used the data from the European case-control study Epilymph on 2,362 lymphoma cases and 2,458 controls to investigate associations between a medical history of infectious and non-infectious diseases with overall and subentity-specific lymphoma risk.
As key results, we observed an increased odds ratio (OR) for self-reported infections with hepatitis B virus (HBV, OR = 1.91, 95% CL = 1.24-2.94) and a null result for rheumatoid arthritis. Additionally, we found an increased OR for infectious mononucleosis (OR = 1.68, 95% CL = 1.14-2.48), an inverse association to frequency of sickness in childhood (OR = 0.68, 95% CL = 0.55-0.84), and-as casual finding-an increased OR with acetaminophen intake (OR = 2.29, 95% CL = 1.49-3.51).
Our results are consistent with the current knowledge about the association with mononucleosis as indicator of Epstein-Barr-virus infection, suggest serological study of the association to HBV infection and do not support the view of a positive association between rheumatoid arthritis and lymphoma risk.
淋巴瘤是一组异质性的免疫细胞恶性肿瘤。免疫相关疾病是少数有一致证据表明与淋巴瘤风险相关的因素之一。
我们使用了欧洲病例对照研究Epilymph中2362例淋巴瘤病例和2458例对照的数据，以研究感染性和非感染性疾病病史与总体及特定亚型淋巴瘤风险之间的关联。
作为主要结果，我们观察到自我报告的乙型肝炎病毒（HBV）感染的优势比（OR）增加（OR = 1.91，95%置信区间[CL] = 1.24 - 2.94），而类风湿性关节炎的结果为阴性。此外，我们发现传染性单核细胞增多症的OR增加（OR = 1.68，95% CL = 1.14 - 2.48），与儿童时期患病频率呈负相关（OR = 0.68，95% CL = 0.55 - 0.84），并且——作为偶然发现——对乙酰氨基酚摄入量的OR增加（OR = 2.29，95% CL = 1.49 - 3.51）。
我们的结果与目前关于传染性单核细胞增多症作为爱泼斯坦 - 巴尔病毒感染指标的关联的认识一致，建议对与HBV感染的关联进行血清学研究，并且不支持类风湿性关节炎与淋巴瘤风险呈正相关的观点。
