Becker Nikolaus, de Sanjose Silvia, Nieters Alexandra, Maynadié Marc, Foretova Lenka, Cocco Pier Luigi, Staines Anthony, Alvaro Tomas, Vornanen Martine, Brennan Paul, Boffetta Paolo
Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Leuk Res. 2007 Oct;31(10):1365-72. doi: 10.1016/j.leukres.2007.02.019. Epub 2007 May 3.
Lymphomas are a heterogeneous group of malignancies of the immune system. Recent studies suggest that immunological conditions which are modulated by lifestyle-dependent environmental determinants might affect lymphoma risk. We used data from Epilymph, a European multi-centric case-control study with 2,480 cases and 2,540 controls, to analyse the relationship between lifestyle-dependent immunological determinants and risk of lymphomas. We found an inverse relationship between risk of lymphoma and allergies, mainly respiratory (OR=0.86, CI=0.89-1.01) and food allergies (OR=0.67, CI=0.52-0.85), a slightly elevated lymphoma risk for first-born children (OR=1.17, CI=0.99-1.39) and only children (OR=1.10, CI=0.86-1.39). The inverse relationship between atopic disorders and risk of lymphomas is consistent with earlier observations. Our findings on birth order and lymphoma increase the inconsistency of findings across studies and suggest a critical reappraisal of potential underlying mechanisms.
淋巴瘤是免疫系统的一组异质性恶性肿瘤。最近的研究表明，受生活方式相关环境决定因素调节的免疫状况可能会影响淋巴瘤风险。我们使用了来自欧洲多中心病例对照研究Epilymph的数据，该研究有2480例病例和2540例对照，以分析生活方式相关免疫决定因素与淋巴瘤风险之间的关系。我们发现淋巴瘤风险与过敏之间存在负相关，主要是呼吸道过敏（OR=0.86，CI=0.89-1.01）和食物过敏（OR=0.67，CI=0.52-至0.85），头胎儿童（OR=1.17，CI=0.99-1.39）和独生子女（OR=1.10，CI=0.86-1.39）的淋巴瘤风险略有升高。特应性疾病与淋巴瘤风险之间的负相关与早期观察结果一致。我们关于出生顺序与淋巴瘤的发现增加了各研究结果的不一致性，并建议对潜在的潜在机制进行批判性重新评估。
