Spafford P D, Mintz D R, Hay J
Division of Otolaryngology, Vancouver General Hospital, B.C., Canada.
J Otolaryngol. 1991 Aug;20(4):262-6.
The purpose of this retrospective review is to study the management of a rare malignant tumor of the parotid gland, the acinic cell carcinoma. Incidence, pathology, clinical findings, and diagnosis are reviewed. Twenty-five patients were seen at the British Columbia Cancer Agency (BCAA) for initial treatment, recurrent disease or follow-up during the period 1958-1990. Twenty-two acinic cell carcinomas (ACC) occurred in the parotid gland. Surgical treatment regimens for parotid ACC ranged from local excision to radical excision. Local excision is not advised but superficial parotidectomy alone appears to have been adequate treatment for small superficial tumors. Eleven of 22 patients received radiotherapy. Indications for adjuvant postoperative radiotherapy are given. Nine patients with primary tumors treated with combined therapy are alive and disease-free with a mean follow-up of 10.7 years. Postoperative radiotherapy appears to be effective in eradicating microscopic residual disease although long-term follow-up is necessary to make these results clinically significant.
本回顾性研究的目的是探讨腮腺罕见恶性肿瘤——腺泡细胞癌的治疗方法。对其发病率、病理、临床特征及诊断进行了回顾。1958年至1990年期间，有25例患者在不列颠哥伦比亚癌症机构（BCAA）接受了初始治疗、复发性疾病治疗或随访。其中22例腺泡细胞癌（ACC）发生于腮腺。腮腺ACC的手术治疗方案从局部切除到根治性切除不等。不建议进行局部切除，但对于小的浅表肿瘤，单纯浅叶腮腺切除术似乎已足够。22例患者中有11例接受了放疗。给出了辅助性术后放疗的指征。9例接受联合治疗的原发性肿瘤患者存活且无疾病，平均随访10.7年。术后放疗似乎对根除微小残留病灶有效，不过需要长期随访以使这些结果具有临床意义。
