建立广泛适用的钯催化含杂原子芳族化合物直接芳基化反应条件。
Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds.
机构信息
Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada.
出版信息
J Org Chem. 2009 Mar 6;74(5):1826-34. doi: 10.1021/jo8026565.
PMID:19206211
Abstract
Conditions for the palladium-catalyzed direct arylation of a wide range of heterocycles with aryl bromides are reported. Those conditions employ a stoichiometric ratio of both coupling partners, as well as a substoichiometric quantity of pivalic acid, which results in significantly faster reactions. An evaluation of the influence of the nature of the aryl halide has also been carried out.
摘要
本文报道了钯催化的广泛杂环与芳基溴的直接芳基化反应的条件。这些条件采用了偶联反应物的化学计量比，以及亚化学计量的特戊酸，这导致反应速度显著加快。还评估了芳基卤化物的性质的影响。
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