使用 TMP-碱对 2-甲基-5-元杂环进行苄基芳基化。
Benzylic arylation of 2-methyl-5-membered heterocycles using TMP-bases.
机构信息
Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 München, Germany.
出版信息
Org Lett. 2012 Apr 20;14(8):1951-3. doi: 10.1021/ol300517q. Epub 2012 Apr 10.
PMID:22489961
Abstract
A new general Pd-catalyzed arylation of various 2-methyl-5-membered heterocycles is reported. This novel method requires Li-, Mg-, or Zn-TMP bases and allows selective metalation of the benzylic position. Subsequent Negishi cross-coupling provides the corresponding arylated heterocycles.
摘要
本文报道了一种新型的钯催化的各种 2-甲基五元杂环的芳基化反应。该新方法需要 Li、Mg 或 Zn-TMP 碱，并允许苄位的选择性金属化。随后的 Negishi 交叉偶联提供了相应的芳基化杂环。
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