用于非共振有机分子无标记分子水平检测的多孔基质。

Porous substrates for label-free molecular level detection of nonresonant organic molecules.

作者信息

Ko Hyunhyub, Chang Sehoon, Tsukruk Vladimir V

机构信息

School of Materials Science and Engineering and School of Polymer, Textile, and Fiber Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.

出版信息

ACS Nano. 2009 Jan 27;3(1):181-8. doi: 10.1021/nn800569f.

DOI:10.1021/nn800569f

PMID:19206265

Abstract

We report on the design of practical surface enhanced Raman scattering (SERS) substrate based upon 3D alumina membranes with cylindrical nanopores chemically modified with polyelectrolyte coating and loaded with gold nanoparticle clusters. These substrates allow for a molecular-level, label-free detection of common plastic explosive materials (TNT, DNT) down to 5-10 zeptograms or 15-30 molecules and a common liquid explosive (HMTD) down to 1 picogram. Such a sensitive detection of organic molecules by utilizing efficient SERS substrates opens the path for affordable and label-free detection of trace amount of practically important chemical compounds.

摘要

我们报道了一种基于三维氧化铝膜的实用表面增强拉曼散射（SERS）基底的设计，该膜具有化学修饰有聚电解质涂层并负载有金纳米粒子簇的圆柱形纳米孔。这些基底能够对常见塑料炸药材料（TNT、DNT）进行分子水平的无标记检测，检测下限低至5 - 10飞克或15 - 30个分子，对常见液体炸药（HMTD）的检测下限低至1皮克。通过利用高效的SERS基底对有机分子进行如此灵敏的检测，为痕量实际重要化合物的经济实惠且无标记检测开辟了道路。