Liong Monty, Lu Jie, Kovochich Michael, Xia Tian, Ruehm Stefan G, Nel Andre E, Tamanoi Fuyuhiko, Zink Jeffrey I
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
ACS Nano. 2008 May;2(5):889-96. doi: 10.1021/nn800072t.
Drug delivery, magnetic resonance and fluorescence imaging, magnetic manipulation, and cell targeting are simultaneously possible using a multifunctional mesoporous silica nanoparticle. Superparamagnetic iron oxide nanocrystals were encapsulated inside mesostructured silica spheres that were labeled with fluorescent dye molecules and coated with hydrophilic groups to prevent aggregation. Water-insoluble anticancer drugs were delivered into human cancer cells; surface conjugation with cancer-specific targeting agents increased the uptake into cancer cells relative to that in non-cancerous fibroblasts. The highly versatile multifunctional nanoparticles could potentially be used for simultaneous imaging and therapeutic applications.
使用多功能介孔二氧化硅纳米颗粒可同时实现药物递送、磁共振和荧光成像、磁操控以及细胞靶向。超顺磁性氧化铁纳米晶体被封装在介孔结构的二氧化硅球体内，这些球体用荧光染料分子标记，并涂覆有亲水基团以防止聚集。将水不溶性抗癌药物递送至人类癌细胞中；与癌症特异性靶向剂的表面偶联相对于非癌成纤维细胞增加了对癌细胞的摄取。这种高度通用的多功能纳米颗粒有可能用于同时进行成像和治疗应用。
