自组装单分子层的质谱分析：分子表面科学的一种新工具。
Mass spectrometry of self-assembled monolayers: a new tool for molecular surface science.
作者信息
Mrksich Milan
机构信息
Department of Chemistry and Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60521, USA.
出版信息
ACS Nano. 2008 Jan;2(1):7-18. doi: 10.1021/nn7004156.
Most reactions can be performed in solution and on a surface, yet the challenges faced in applying known reactions or in developing entirely new reactions for modifying surfaces remain formidable. The products of many reactions performed in solution can be characterized in minutes, and even products having complex structures can be characterized in hours. When performed on surfaces, even the most basic reactions require a substantial effort--requiring several weeks--to characterize the yields and structures of the products. This contrast stems from the lack of convenient analytical tools that provide rapid information on the structures of molecules attached to a surface. This review describes recent work that has established mass spectrometry as a powerful method for developing and characterizing a broad range of chemical reactions of molecules attached to self-assembled monolayers of alkanethiolates on gold. The SAMDI-TOF mass spectrometry technique will enable a next generation of applications of molecularly defined surfaces to problems in chemistry and biology.
大多数反应既可以在溶液中进行，也可以在表面上进行，然而，在应用已知反应或开发用于修饰表面的全新反应时所面临的挑战仍然十分艰巨。在溶液中进行的许多反应的产物可以在几分钟内得到表征，即使是具有复杂结构的产物也能在几小时内得到表征。而在表面上进行反应时，即使是最基本的反应也需要付出巨大努力（需要数周时间）来表征产物的产率和结构。这种差异源于缺乏便捷的分析工具，无法快速提供附着在表面的分子结构信息。本综述描述了近期的工作，这些工作已将质谱法确立为一种强大的方法，用于开发和表征与金表面上的烷硫醇自组装单分子层相连的分子的广泛化学反应。表面辅助激光解吸电离飞行时间质谱（SAMDI-TOF）技术将使分子定义表面在化学和生物学问题上的新一代应用成为可能。
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