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Pharmacogenomic genome-wide association studies: lessons learned thus far.

作者信息

Crowley James J, Sullivan Patrick F, McLeod Howard L

出版信息

Pharmacogenomics. 2009 Feb;10(2):161-3. doi: 10.2217/14622416.10.2.161.

DOI:10.2217/14622416.10.2.161
PMID:19207016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3893087/
Abstract
摘要

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1
Genetic mapping in human disease.人类疾病中的基因定位
Science. 2008 Nov 7;322(5903):881-8. doi: 10.1126/science.1156409.
2
Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder.187名注意力缺陷多动障碍儿童对哌甲酯反应的全基因组关联研究。
Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1412-8. doi: 10.1002/ajmg.b.30865.
3
SLCO1B1 variants and statin-induced myopathy--a genomewide study.溶质载体有机阴离子转运体家族1成员B1（SLCO1B1）变异与他汀类药物诱发的肌病——一项全基因组研究
N Engl J Med. 2008 Aug 21;359(8):789-99. doi: 10.1056/NEJMoa0801936. Epub 2008 Jul 23.
4
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.全基因组关联扫描鉴定出与类风湿关节炎抗TNF治疗反应差异相关的候选多态性。
Mol Med. 2008 Sep-Oct;14(9-10):575-81. doi: 10.2119/2008-00056.Liu.
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Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis.双膦酸盐相关颌骨坏死与多发性骨髓瘤中细胞色素P450 CYP2C8的多态性相关：一项全基因组单核苷酸多态性分析
Blood. 2008 Oct 1;112(7):2709-12. doi: 10.1182/blood-2008-04-147884. Epub 2008 Jul 1.
6
Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.基因组关联分析表明12号染色体位点影响对噻嗪类利尿剂的降压反应。
Hypertension. 2008 Aug;52(2):359-65. doi: 10.1161/HYPERTENSIONAHA.107.104273. Epub 2008 Jun 30.
7
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.一项针对对华法林维持剂量有重大影响的常见基因变异的全基因组扫描。
Blood. 2008 Aug 15;112(4):1022-7. doi: 10.1182/blood-2008-01-134247. Epub 2008 Jun 5.
8
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Mol Psychiatry. 2009 Nov;14(11):1024-31. doi: 10.1038/mp.2008.52. Epub 2008 Jun 3.
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Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia.基于通路的全基因组筛选数据关联分析表明，与γ-氨基丁酸受体信号通路相关的基因参与了抗精神病药物诱发的难治性迟发性运动障碍。
Pharmacogenet Genomics. 2008 Apr;18(4):317-23. doi: 10.1097/FPC.0b013e3282f70492.
10
Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis.多发性硬化症中干扰素β治疗反应的全基因组药物基因组学分析。
Arch Neurol. 2008 Mar;65(3):337-44. doi: 10.1001/archneurol.2008.47. Epub 2008 Jan 14.