Parry-Fielder Bronwyn, Collins Kevin, Fisher John, Keir Eddie, Anderson Vicki, Jacobs Rani, Scheffer Ingrid E, Nolan Terry
Royal Children's Hospital, Melbourne, Australia.
Dev Med Child Neurol. 2009 Mar;51(3):228-34. doi: 10.1111/j.1469-8749.2008.03163.x. Epub 2009 Jan 29.
Earlier research has suggested a link between epileptiform activity in the electroencephalogram (EEG) and developmental speech-language disorder (DSLD). This study investigated the strength of this association by comparing the frequency of EEG abnormalities in 45 language-normal children (29 males, 16 females; mean age 6y 11mo, SD 1y 10mo, range 4y-9y 10mo) and 54 community-ascertained children (35 males, 19 females; mean age 5y 7mo, SD 1y 6mo, range 4y-9y 11mo) with a diagnosis of severe DSLD, defined as a score at least 2 SD below the mean on at least one speech-language measure, and a performance IQ of at least 80 points. All participants underwent sleep EEGs after sedation. Children with DSLD also had detailed speech-language, hearing, and psychological assessments. Results failed to support the previously identified strong association between abnormal EEG and DSLD. There was a weak, non-significant relationship between DSLD and epileptiform EEG. Epileptiform EEG was significantly associated with low performance IQ (p=0.04). This study draws into question previously reported associations between epileptiform activity and DSLD probably because it examined a purer cohort of children with more severe language difficulties who did not have seizures.
早期研究表明，脑电图（EEG）中的癫痫样活动与发育性言语语言障碍（DSLD）之间存在联系。本研究通过比较45名语言正常儿童（29名男性，16名女性；平均年龄6岁11个月，标准差1岁10个月，范围4岁至9岁10个月）和54名经社区确诊的患有严重DSLD的儿童（35名男性，19名女性；平均年龄5岁7个月，标准差1岁6个月，范围4岁至9岁11个月）的EEG异常频率，来调查这种关联的强度。严重DSLD的定义为在至少一项言语语言测量中得分至少比平均水平低2个标准差，且操作智商至少为80分。所有参与者在镇静后接受睡眠EEG检查。患有DSLD的儿童还进行了详细的言语语言、听力和心理评估。结果未能支持先前确定的异常EEG与DSLD之间的强关联。DSLD与癫痫样EEG之间存在微弱的、无统计学意义的关系。癫痫样EEG与低操作智商显著相关（p = 0.04）。本研究对先前报道的癫痫样活动与DSLD之间的关联提出了质疑，可能是因为它研究了一组更纯粹的、语言困难更严重且无癫痫发作的儿童。
