Epilepsy Center Kempenhaeghe, Heeze, The Netherlands.
Pediatr Neurol. 2011 May;44(5):333-9. doi: 10.1016/j.pediatrneurol.2010.10.014.
In clinical practice, an association is commonly suggested between nocturnal epileptiform activity and language disorders in children. However, this association has not been studied systematically. This study explored the correlation between daily and nocturnal epileptiform discharges ratio, frequency of nocturnal epileptiform discharges, and severity of nocturnal seizures in correlation with the severity of language impairment. A total of 326 children referred to an epilepsy center were included. All children had a 24-hour electroencephalogram (EEG), a neuropsychologic assessment, and a reconfirmed diagnosis of epilepsy. The balance between verbal and performance IQ scores of the Wechsler Intelligence Scale for Children was a focus of the study. A significant correlation between the severity of nocturnal seizures and lower verbal IQ scores compared to performance IQ scores was found (P < 0.05). There was a clinically relevant difference between performance IQ and verbal IQ between the groups of children with only nocturnal epileptiform EEG discharges and only epileptiform EEG discharges during wake (P = 0.033). Children with nocturnal epileptiform EEG discharges have lower verbal than performance IQs when compared to children with only epileptiform EEG discharges during wake. Although a causal relationship is unclear, this indicates an association between the occurrence of nocturnal epileptiform EEG discharges and language disturbance.
在临床实践中，通常认为夜间癫痫样活动与儿童语言障碍之间存在关联。然而，这种关联尚未得到系统研究。本研究旨在探讨昼夜癫痫样放电比例、夜间癫痫样放电频率和夜间癫痫发作严重程度与语言障碍严重程度之间的相关性。共有 326 名儿童被纳入癫痫中心。所有儿童均进行了 24 小时脑电图（EEG）、神经心理学评估，并对癫痫进行了重新确认诊断。韦氏儿童智力量表的言语和操作智商得分平衡是本研究的重点。夜间癫痫发作的严重程度与言语智商得分明显低于操作智商得分相关（P<0.05）。仅在夜间出现癫痫样 EEG 放电和仅在觉醒时出现癫痫样 EEG 放电的两组儿童之间，操作智商和言语智商之间存在临床相关差异（P=0.033）。与仅在觉醒时出现癫痫样 EEG 放电的儿童相比，夜间出现癫痫样 EEG 放电的儿童言语智商明显低于操作智商。尽管因果关系尚不清楚，但这表明夜间癫痫样 EEG 放电的发生与语言障碍之间存在关联。
