Yoshida Aki, Takahashi Kazuhiro, Tagami Hachiro, Akasaka Toshihide
Department of Dermatology, Iwate Medical University School of Medicine, Morioka, Japan.
J Dermatol. 2009 Jan;36(1):56-9. doi: 10.1111/j.1346-8138.2008.00586.x.
Primary localized cutaneous amyloidosis can take several clinical forms. In Asia, macular amyloidosis caused by prolonged friction from a rough nylon towel or brush is common, and macular amyloidosis and lichen amyloidosis occasionally occur together, as so-called biphasic amyloidosis. We report herein the case of an 83-year-old Japanese man with lichen amyloidosis caused by prolonged nylon towel friction. This patient presented with unique symmetrical papular lesions on the upper back and shoulders. Lesions comprised slightly shiny, brownish, fine uniform papules approximately 0.5 mm in diameter, showing a partially linear, annular or rippled arrangement. Although this case was caused by prolonged nylon towel friction, no coexisting macular lesions could be found. To the best of our knowledge, this represents the first case of lichen amyloidosis induced by nylon towel friction in the absence of the macular amyloidosis that is usually observed in such cases. We instructed the patient to stop the habit of nylon towel rubbing and prescribed a topical steroid ointment and cepharanthine. After 6 months of treatment, papular lesions became clearly flatter.
原发性局限性皮肤淀粉样变可有多种临床形式。在亚洲,由粗糙尼龙毛巾或刷子长时间摩擦引起的斑状淀粉样变很常见,斑状淀粉样变和苔藓样淀粉样变偶尔会同时出现,即所谓的双相淀粉样变。我们在此报告一例83岁日本男性因尼龙毛巾长时间摩擦导致苔藓样淀粉样变的病例。该患者上背部和肩部出现独特的对称性丘疹性皮损。皮损由直径约0.5毫米、略带光泽、褐色、细小均匀的丘疹组成,呈部分线状、环状或波纹状排列。虽然该病例由尼龙毛巾长时间摩擦引起,但未发现并存的斑状皮损。据我们所知,这是首例在通常此类病例中会出现的斑状淀粉样变缺失的情况下,由尼龙毛巾摩擦诱发的苔藓样淀粉样变病例。我们嘱咐患者停止用尼龙毛巾擦拭的习惯,并开具了外用类固醇软膏和千金藤素。治疗6个月后,丘疹性皮损明显变平。