Cai Xintian, Zhu Qing, Wu Ting, Zhu Bin, Liu Shasha, Liu Shanshan, Aierken Xiayire, Ahmat Ayguzal, Li Nanfang
Center for Hypertension of The People's Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang, Urumqi, Xinjiang 830001, P.R. China.
Exp Ther Med. 2020 Feb;19(2):1033-1041. doi: 10.3892/etm.2019.8306. Epub 2019 Dec 9.
The present meta-analysis was performed to examine the association between circulating blood adipokine levels and Kawasaki disease (KD). Studies were identified by searching various databases, including Web of Science, EMBASE, PubMed, Wanfang and China National Knowledge Infrastructure. After the studies were pooled, the mean difference (MD) and corresponding 95% CI were calculated. Subgroup analyses and publication bias detection were also performed. The Cochrane Q test and I statistics were performed using Review Manager software (version 5.3) to test for heterogeneity. A Begg's test was used to assess publication bias and STATA software (version 12.0) was used for statistical analysis. The results revealed that the KD group exhibited higher levels of resistin compared with those in the healthy controls or disease controls (non-KD; MD=20.76, 95% CI=16.16-25.36, P<0.001; MD=21.27, 95% CI=14.24-28.29, P<0.001, respectively). In addition, when compared with those in patients exhibiting non-coronary artery lesions (NCAL), those with coronary artery lesions (CAL) had higher levels of adiponectin and resistin (MD=1.00, 95% CI=0.06-1.96, P=0.04; MD=2.77, 95% CI=1.32-4.22, P<0.001). Furthermore, compared with those in the inactive-phase group, patients in the active-phase group exhibited higher levels of resistin (MD=17.73, 95% CI=12.82-22.65, P<0.001). In conclusion, the present meta-analysis indicated that resistin levels were elevated in patients with KD. It was also revealed that circulating resistin and adiponectin levels in the CAL group were significantly increased compared with those in patients with NCAL. Furthermore, the active group had higher levels of resistin than the inactive group. The results of these meta-analyses indicated that resistin may serve an important role in the pathogenesis of KD and may therefore be used as biomarkers for the diagnosis of KD, whereas adiponectin may only serve an important role in the pathogenesis of CAL and may therefore be used as a biomarker to distinguish CAL from NCAL.
本荟萃分析旨在研究循环血液中脂肪因子水平与川崎病（KD）之间的关联。通过检索多个数据库来确定相关研究，包括科学网、EMBASE、PubMed、万方和中国知网。在汇总这些研究后，计算平均差（MD）及相应的95%置信区间（CI）。还进行了亚组分析和发表偏倚检测。使用Review Manager软件（5.3版）进行Cochrane Q检验和I统计量分析以检验异质性。采用Begg检验评估发表偏倚，并使用STATA软件（12.0版）进行统计分析。结果显示，与健康对照组或疾病对照组（非KD）相比，KD组的抵抗素水平更高（MD = 20.76，95% CI = 16.16 - 25.36，P < 0.001；MD = 21.27，95% CI = 14.24 - 28.29，P < 0.001）。此外，与无冠状动脉病变（NCAL）的患者相比，有冠状动脉病变（CAL）的患者脂联素和抵抗素水平更高（MD = 1.00，95% CI = 0.06 - 1.96，P = 0.04；MD = 2.77，95% CI = 1.32 - 4.22，P < 0.001）。此外，与非活动期组相比，活动期组患者的抵抗素水平更高（MD = 17.73，95% CI = 12.82 - 22.65，P < 0.001）。总之，本荟萃分析表明，KD患者的抵抗素水平升高。还发现，与NCAL患者相比，CAL组的循环抵抗素和脂联素水平显著升高。此外，活动组的抵抗素水平高于非活动组。这些荟萃分析结果表明，抵抗素可能在KD的发病机制中起重要作用，因此可用作KD诊断的生物标志物，而脂联素可能仅在CAL的发病机制中起重要作用，因此可用作区分CAL与NCAL的生物标志物。
