Mycoses. 2010 Jan;53(1):84-8. doi: 10.1111/j.1439-0507.2008.01671.x. Epub 2009 Jan 21.
Among fungi, Curvularia inaequalis is a rare pathogen. We report the first case of non-invasive fungal rhinosinusitis caused by this species. Endoscopic sinus surgery revealed massive polyposis and the presence of viscous eosinophilic mucus that allowed the growth of the fungus. We diagnosed eosinophilic fungal rhinosinusitis based on the histological findings of fungal hyphae in association with degranulating eosinophils in the sinus mucus. After polypectomy and clearance of the affected sinuses, oral itraconazole was administered to prevent the recurrence. Given the ever-increasing list of opportunistic fungi that cause human infection, the case reported here provides further evidence that proper identification of the infective agents remains crucial for the patient's management.
在真菌中，新月弯孢霉是一种罕见的病原体。我们报告了首例由该种真菌引起的非侵袭性真菌性鼻-鼻窦炎。内镜鼻窦手术显示大量息肉形成，并存在粘性嗜酸性黏液，有利于真菌生长。我们根据鼻窦黏液中真菌菌丝与脱颗粒嗜酸性粒细胞相关的组织学发现诊断为嗜酸性真菌性鼻-鼻窦炎。在息肉切除和清除受累鼻窦后，给予口服伊曲康唑以预防复发。鉴于引起人类感染的机会性真菌的名单不断增加，这里报告的病例进一步表明，正确鉴定感染因子对患者的治疗仍然至关重要。
