谷氨酸受体在小鼠的神经肌肉接头处定位于突触后。
Glutamate receptors localize postsynaptically at neuromuscular junctions in mice.
作者信息
Mays Tessily A, Sanford Jamie L, Hanada Toshihiko, Chishti Athar H, Rafael-Fortney Jill A
机构信息
Department of Molecular and Cellular Biochemistry, 410 Hamilton Hall, College of Medicine, Ohio State University, 1645 Neil Avenue, Columbus, Ohio 43210, USA.
出版信息
Muscle Nerve. 2009 Mar;39(3):343-9. doi: 10.1002/mus.21099.
Abstract
Dlg (Discs Large) is a multidomain protein that interacts with glutamate receptors and potassium channels at Drosophila neuromuscular junctions (NMJs) and at mammalian central nervous system synapses. Dlg also localizes postsynaptically at cholinergic mammalian NMJs. We show here that alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate (AMPA) receptor subunits, together with glutamate, are present at the mammalian NMJ. Both AMPA and NMDA (N-methyl-D-aspartate) glutamate receptor subunits display overlapping postsynaptic localization patterns with Dlg at all NMJs examined in normal mice. Kir2 potassium channels also localize with Dlg and glutamate receptors at this synapse. Localization of the components of a glutamatergic system suggests novel mechanisms at mammalian neuromuscular synapses.
摘要
Dlg（大圆盘蛋白）是一种多结构域蛋白，它在果蝇神经肌肉接头（NMJ）以及哺乳动物中枢神经系统突触处与谷氨酸受体和钾通道相互作用。Dlg在哺乳动物胆碱能神经肌肉接头的突触后也有定位。我们在此表明，α-氨基-3-羟基-5-甲基异恶唑-4-丙酸（AMPA）受体亚基与谷氨酸一起存在于哺乳动物神经肌肉接头处。在正常小鼠中检查的所有神经肌肉接头处，AMPA和NMDA（N-甲基-D-天冬氨酸）谷氨酸受体亚基都与Dlg呈现出重叠的突触后定位模式。Kir2钾通道在这个突触处也与Dlg和谷氨酸受体共定位。谷氨酸能系统各组分的定位提示了哺乳动物神经肌肉突触处的新机制。
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2
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Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):335-40. doi: 10.1073/pnas.0607450104. Epub 2006 Dec 26.
3
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4
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J Neurosci. 2006 Feb 22;26(8):2343-57. doi: 10.1523/JNEUROSCI.5247-05.2006.
5
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6
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J Neurochem. 2005 Jul;94(1):257-67. doi: 10.1111/j.1471-4159.2005.03194.x.
7
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8
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