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成年小鼠神经挤压后，神经肌肉谷氨酸受体的阻断会损害神经再支配。

Blockage of neuromuscular glutamate receptors impairs reinnervation following nerve crush in adult mice.

作者信息

Personius Kirkwood E, Siebert Danielle, Koch Dennis W, Udin Susan B

机构信息

Program in Neuroscience, School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States.

Department of Rehabilitation Science, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United States.

出版信息

Front Cell Neurosci. 2022 Sep 22;16:1000218. doi: 10.3389/fncel.2022.1000218. eCollection 2022.

DOI:10.3389/fncel.2022.1000218
PMID:36212695
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9535682/
Abstract

Motor axons in peripheral nerves are capable of regeneration following injury. However, complete recovery of motor function is rare, particularly when reinnervation is delayed. We have previously found that glutamate receptors play a crucial role in the successful innervation of muscle during mouse development. In particular, blocking N-methyl-D-aspartate (NMDA) receptor activity delays the normal elimination of excess innervation of each neuromuscular junction. Here, we use behavioral, immunohistochemical, electrophysiological, and calcium imaging methods to test whether glutamate receptors play a similar role in the transition from polyneuronal to mono-innervation and in recovery of function following peripheral nerve injury in mature muscle.

摘要

外周神经中的运动轴突在损伤后能够再生。然而，运动功能的完全恢复很少见，尤其是当神经再支配延迟时。我们之前发现，谷氨酸受体在小鼠发育过程中肌肉的成功神经支配中起着关键作用。特别是，阻断N-甲基-D-天冬氨酸（NMDA）受体活性会延迟每个神经肌肉接头多余神经支配的正常消除。在这里，我们使用行为学、免疫组织化学、电生理学和钙成像方法来测试谷氨酸受体在成熟肌肉从多神经元支配向单神经元支配的转变以及外周神经损伤后功能恢复中是否发挥类似作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/fcd29549353f/fncel-16-1000218-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/12db02f0758b/fncel-16-1000218-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/39e8de3cdf94/fncel-16-1000218-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/81a12d8d9477/fncel-16-1000218-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/afc030b36fb8/fncel-16-1000218-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/fcd29549353f/fncel-16-1000218-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/12db02f0758b/fncel-16-1000218-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/39e8de3cdf94/fncel-16-1000218-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/81a12d8d9477/fncel-16-1000218-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/afc030b36fb8/fncel-16-1000218-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aedb/9535682/fcd29549353f/fncel-16-1000218-g005.jpg

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