Garzoni Christian, Kelley William L
Departement of Infectious Diseases, Inselspital, Bern University Hospital and University of Bern, CH-3010 Bern, Switzerland.
Trends Microbiol. 2009 Feb;17(2):59-65. doi: 10.1016/j.tim.2008.11.005. Epub 2009 Feb 7.
Many reports have documented that Staphylococcus aureus can invade host cells and persist intracellularly for various periods of time in cell culture models. However, it is not clear whether intracellular persistence of S. aureus also occurs in the course of infections in whole organisms. This is a subject of intense debate and is difficult to assess experimentally. Intracellular persistence would provide S. aureus with an ideal strategy to escape from professional phagocytes and extracellular antibiotics and would promote recrudescent infection. Here, we present a brief overview of the mounting evidence that S. aureus has the potential to internalize and survive within host cells.
许多报告已证明，在细胞培养模型中，金黄色葡萄球菌能够侵入宿主细胞并在细胞内持续存在不同时长。然而，尚不清楚金黄色葡萄球菌在整个生物体感染过程中是否也会在细胞内持续存在。这是一个激烈争论的话题，且难以通过实验进行评估。细胞内持续存在将为金黄色葡萄球菌提供一种理想策略，使其能够逃避专职吞噬细胞和细胞外抗生素的作用，并促进复发感染。在此，我们简要概述越来越多的证据，这些证据表明金黄色葡萄球菌有潜力在宿主细胞内内化并存活。
