Hu C-C, Ho J-D, Lin H-C
College of Medicine, Taipei Medical University, Taipei, Taiwan.
Br J Ophthalmol. 2009 Jun;93(6):717-20. doi: 10.1136/bjo.2008.151605. Epub 2009 Feb 10.
Using a nationwide population-based dataset, this study investigated the relationship between retinal vein occlusion (RVO) and subsequent acute myocardial infarction (AMI).
This study is based on a nationwide database released by the Taiwan National Health Research Institute. The study cohort consisted of all ambulatory care patients who were diagnosed as having RVO during 2000 approximately 2003 (n = 591), while the control cohort comprised 2955 randomly selected patients extracted from the same dataset; five patients for every RVO patient, matched by age and gender. Each patient was individually tracked for 3 years from their index ambulatory care visit. Cox proportional hazard regressions were performed to compute the adjusted 3-year AMI-free survival rates, comparing these two cohorts.
RVO patients had a significantly higher rate of AMI (1.86% vs 0.78%) during the 3-year follow-up period than patients in the comparison group (p = 0.032). However, after adjusting for the patients' gender, age, geographic region and comorbid medical disorders, there was no significant difference between the central retinal vein occlusion, branch retinal vein occlusion patients and the comparison group in terms of the hazard of AMI during the 3-year follow-up period.
RVO did not independently increase the risk of AMI.
本研究利用全国性基于人群的数据集，调查视网膜静脉阻塞（RVO）与随后急性心肌梗死（AMI）之间的关系。
本研究基于台湾国家卫生研究院发布的全国性数据库。研究队列包括2000年至2003年期间被诊断为患有RVO的所有门诊患者（n = 591），而对照队列由从同一数据集中随机选取的2955名患者组成；每例RVO患者对应5名患者，按年龄和性别匹配。从每位患者的首次门诊就诊开始对其进行为期3年的个体追踪。进行Cox比例风险回归分析以计算调整后的3年无AMI生存率，比较这两个队列。
在3年随访期内，RVO患者的AMI发生率（1.86%对0.78%）显著高于对照组患者（p = 0.032）。然而，在对患者的性别、年龄、地理区域和合并症进行调整后，在3年随访期内，中央视网膜静脉阻塞、分支视网膜静脉阻塞患者与对照组在AMI风险方面无显著差异。
RVO并不会独立增加AMI风险。
