A激酶锚定蛋白10激酶结合结构域中的Ile646Val（2073A>G）多态性与结直肠癌风险

The Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 and the risk of colorectal cancer.

作者信息

Wang Mo-Jin, Zhou Zong-Guang, Wang Ling, Yu Yong-Yang, Zhang Peng, Zhang Yi, Cui Chang-Fu, Yang Lie, Li Yuan, Zhou Bin, Sun Xiao-Feng

机构信息

Institute of Digestive Surgery, Department of Colorectal Surgery and National Key Laboratory of Biotherapy of West China Hospital, Sichuan University, Chengdu, China.

出版信息

Oncology. 2009;76(3):199-204. doi: 10.1159/000201572. Epub 2009 Feb 11.

DOI:10.1159/000201572

PMID:19209010

Abstract

OBJECTIVE

The purpose of this study is to investigate whether the Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of colorectal cancer (CRC), clinicopathological variables and the environmental factors for the development of CRC.

METHODS

Applying TaqMan allelic discrimination, we investigated AKAP10 Ile646Val (2073A>G) polymorphism in 288 Chinese CRC patients and 281 healthy controls.

RESULTS

Logistic regression analysis revealed a significant association of AKAP10 Ile646Val (2073A>G) polymorphism with increased CRC risk (adjusted OR = 1.44, 95% CI 1.01-2.07, p = 0.02). Stratification analysis showed that the increased risk associated with the variant genotypes (GG+AG) was more evident in male subjects (adjusted OR = 1.48, 95% CI 0.94-2.34, p = 0.03). Compared with the AA genotype, the adjusted OR for the variant genotypes was 1.81 (95% CI 1.08-3.05, p = 0.01) among young subjects (age <57 years). Among individuals who did not smoke or who smoked lightly, there was a significantly increased risk with the variant genotypes (adjusted OR = 1.66, 95% CI 1.08-2.56, p = 0.02). We did not observe a relationship between the AKAP10 polymorphism and other clinicopathological and environmental factors.

CONCLUSIONS

Our data suggested that the AKAP10 2073A>G variation is associated with an increased risk of CRC in the Chinese population.

摘要

目的

本研究旨在探究A激酶锚定蛋白10（AKAP10）激酶结合域中的Ile646Val（2073A>G）多态性是否与结直肠癌（CRC）风险、临床病理变量以及CRC发生的环境因素相关。

方法

应用TaqMan等位基因鉴别技术，我们对288例中国CRC患者和281例健康对照者的AKAP10 Ile646Val（2073A>G）多态性进行了研究。

结果

逻辑回归分析显示，AKAP10 Ile646Val（2073A>G）多态性与CRC风险增加显著相关（校正比值比=1.44，95%可信区间1.01-2.07，p=0.02）。分层分析表明，与变异基因型（GG+AG）相关的风险增加在男性受试者中更为明显（校正比值比=1.48，95%可信区间0.94-2.34，p=0.03）。与AA基因型相比，年轻受试者（年龄<57岁）中变异基因型的校正比值比为1.81（95%可信区间1.08-3.05，p=0.01）。在不吸烟或轻度吸烟的个体中，变异基因型的风险显著增加（校正比值比=1.66，95%可信区间1.08-2.56，p=0.02）。我们未观察到AKAP10多态性与其他临床病理和环境因素之间的关系。