一名患有永久性先天性甲状腺功能减退症的婴儿及其患有暂时性先天性甲状腺功能减退症的双胞胎中循环抗甲状腺激素自身抗体的检测：甲状腺激素自身抗体对新生儿和婴儿甲状腺功能减退症的可能影响。

Detection of circulating autoantibodies against thyroid hormones in an infant with permanent congenital hypothyroidism and her twin with transient congenital hypothyroidism: possible contribution of thyroid hormone autoantibodies to neonatal and infant hypothyroidism.

作者信息

Benvenga Salvatore, Ordookhani Arash, Pearce Elizabeth N, Tonacchera Massimo, Azizi Fereidoun, Braverman Lewis E

机构信息

Sezione di Endocrinologia, Dipartimento Clinico Sperimentale di Medicina e Farmacologia, Policlinico Universitario di Messina, Italy.

出版信息

J Pediatr Endocrinol Metab. 2008 Oct;21(10):1011-20. doi: 10.1515/jpem.2008.21.10.1011.

DOI:10.1515/jpem.2008.21.10.1011

PMID:19209623

Abstract

Premature, very-low-birth-weight female twins were diagnosed with congenital hypothyroidism (CH). Thyroid hormone antibodies (THAb) directed against triiodothyronine (T3) and thyroxine (T4) of both the IgM and IgG class were detected in both twins. At age 10 months, a rise in thyroid stimulating hormone (TSH) occurred in both infants and measurement of THAb at the same time revealed the appearance of IgM-T4 and IgG-T4 and an increase in IgG-T3 levels in twin 1 (permanent CH), and with a slight increase of IgM-T4 and IgG-T4 levels and appearance of IgM-T3 in twin 2 (transient CH). THAb may contribute to the induction of hypothyroidism in neonates and infants, especially those with underlying autoimmune thyroid disease.

摘要

早产的极低出生体重雌性双胞胎被诊断为先天性甲状腺功能减退症（CH）。在这对双胞胎中均检测到了针对三碘甲状腺原氨酸（T3）和甲状腺素（T4）的IgM和IgG类甲状腺激素抗体（THAb）。在10个月大时，两个婴儿的促甲状腺激素（TSH）均升高，同时检测THAb发现，双胞胎1（永久性CH）出现了IgM-T4和IgG-T4，且IgG-T3水平升高；双胞胎2（暂时性CH）的IgM-T4和IgG-T4水平略有升高，并出现了IgM-T3。THAb可能有助于新生儿和婴儿甲状腺功能减退症的诱发，尤其是那些患有潜在自身免疫性甲状腺疾病的患儿。