伊朗马尔卡齐省先天性甲状腺功能减退症的流行病学
Epidemiology of congenital hypothyroidism in Markazi Province, Iran.
作者信息
Dorreh Fatemeh, Chaijan Parsa Y, Javaheri Javad, Zeinalzadeh Ali Hossein
机构信息
abriz University of Medical Sciences, National Public Health Management Center, Department of Community Medicine, Tabriz, Iran. E-ma-il:
出版信息
J Clin Res Pediatr Endocrinol. 2014;6(2):105-10. doi: 10.4274/Jcrpe.1287.
OBJECTIVE
The aim of this study was to investigate the epidemiology of congenital hypothyroidism (CH) among newborns in Markazi Province, Iran.
METHODS
This cross-sectional study was conducted from 2006 to 2012. Blood samples were taken between 3 to 5 days after birth from the heel. Thyroid stimulating hormone (TSH) was tested using the enzyme-linked immunosorbent assay method and was employed as the screening test. Newborns with abnormal screening results (TSH >5 mIU/L) were re-examined. The data were analyzed using SPSS.
RESULTS
A total of 127 112 infants were screened. Of these, 51.2% were male and 48.8% were female. The coverage rate of the screening program was 100%. Of 6102 recalled subjects (re-call rate 4.8%), 414 cases with CH were detected, yielding a CH prevalence of 1:307 (female:male ratio 1:0.95). The prevalence of permanent and transient CH was 1:581 and 1:628, respectively.
CONCLUSION
This study reveals that the prevalence of CH is higher compared to worldwide levels. Comprehensive and complementary studies for recognizing related risk factors should be a priority for health system research in this province.
目的
本研究旨在调查伊朗马尔卡齐省新生儿先天性甲状腺功能减退症（CH）的流行病学情况。
方法
本横断面研究于2006年至2012年进行。在出生后3至5天从足跟采集血样。采用酶联免疫吸附测定法检测促甲状腺激素（TSH），并将其用作筛查试验。对筛查结果异常（TSH>5 mIU/L）的新生儿进行复查。使用SPSS对数据进行分析。
结果
共筛查了127112名婴儿。其中，51.2%为男性，48.8%为女性。筛查项目的覆盖率为100%。在6102名被召回的受试者中（召回率4.8%），检测出414例CH病例，CH患病率为1:307（女性:男性比例为1:0.95）。永久性和暂时性CH的患病率分别为1:581和1:628。
结论
本研究表明，CH的患病率高于全球水平。识别相关危险因素的综合和补充研究应成为该省卫生系统研究的优先事项。
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