Wada T, Motoo Y, Ohmizo R, Terada T, Nakanuma Y
Department of Internal Medicine, Ushitsu General Hospital, Ishikawa, Japan.
Jpn J Med. 1991 May-Jun;30(3):278-80. doi: 10.2169/internalmedicine1962.30.278.
A 51-year-old female was admitted to the hospital due to liver dysfunction. She had suffered from arthralgia, Raynaud's phenomenon, dry mouth and dry eyes. Laboratory data showed positive LE cells and anti-RNP. The diagnosis of mixed connective tissue disease (MCTD) was made according to the criteria of the international symposium on MCTD and Antinuclear Antibodies (August 1986, Tokyo). Liver biopsy showed chronic active hepatitis. The results of sialography, lip biopsy and rose-bengal test were compatible with Sjögren's syndrome (SjS). This is the report of a rare case with MCTD associated with SjS and autoimmune hepatitis.
一名51岁女性因肝功能障碍入院。她有关节痛、雷诺现象、口干和眼干症状。实验室检查显示狼疮细胞和抗核糖核蛋白抗体呈阳性。根据1986年8月在东京召开的混合性结缔组织病和抗核抗体国际研讨会的标准，诊断为混合性结缔组织病（MCTD）。肝脏活检显示为慢性活动性肝炎。唾液腺造影、唇腺活检和玫瑰红试验结果符合干燥综合征（SjS）。本文报告了一例罕见的MCTD合并SjS及自身免疫性肝炎的病例。
