Hart Reece K, Mukhyala Kiran
Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
Pac Symp Biocomput. 2009:403-14.
This paper describes the design and applications of Unison, a comprehensive and integrated warehouse of protein sequences, diverse precomputed predictions, and other biological data. Unison provides a practical solution to the burden of preparing data for computational discovery projects, enables holistic feature-based mining queries regarding protein composition and functions, and provides a foundation for the development of new tools. Unison is available for immediate use online via direct database connections and a web interface. In addition, the database schema, command line tools, web interface, and non-proprietary precomputed predictions are released under the Academic Free License and available for download at http://unison-db.org/. This project has resulted in a system that significantly reduces several practical impediments to the initiation of computational biology discovery projects.
本文介绍了Unison，一个全面集成的蛋白质序列仓库、各种预先计算的预测结果以及其他生物数据。Unison为计算发现项目的数据准备负担提供了切实可行的解决方案，支持基于整体特征的蛋白质组成和功能挖掘查询，并为新工具的开发奠定了基础。通过直接数据库连接和网络界面，可立即在线使用Unison。此外，数据库模式、命令行工具、网络界面以及非专有预先计算的预测结果均根据学术自由许可发布，可从http://unison-db.org/下载。该项目开发出的系统显著减少了启动计算生物学发现项目的几个实际障碍。
