Vrhovski Bernadette, Thézé Nadine, Thiébaud Pierre
Oncology Research Unit The Children's Hospital at Westmead, New South Wales, Australia.
Adv Exp Med Biol. 2008;644:6-26. doi: 10.1007/978-0-387-85766-4_2.
Tropomyosins constitute a family of highly related actin-binding proteins found in the animal kingdom from yeast to human. In vertebrates, they are encoded by a multigene family where each member can produce several isoforms through alternative splicing and for some of them with alternate promoters. Tropomyosin isoform diversity has considerably increased during evolution from invertebrates to vertebrates and stems from the duplication of ancestral genes. The advance ofgenomic sequence information on various animals has expanded our knowledge on the structure of tropomyosin genes in different phyla and subphyla. We present the organisation of tropomyosin genes in different major phyla and the phylogenetic comparison of their structure highlights the evolution of this multigene family.
原肌球蛋白构成了一类高度相关的肌动蛋白结合蛋白家族，从酵母到人类的动物界中均有发现。在脊椎动物中，它们由一个多基因家族编码，其中每个成员可通过可变剪接产生多种异构体，并且其中一些还具有交替启动子。从无脊椎动物到脊椎动物的进化过程中，原肌球蛋白异构体的多样性显著增加，这源于祖先基因的复制。各种动物基因组序列信息的发展扩展了我们对不同门和亚门中原肌球蛋白基因结构的认识。我们展示了不同主要门中原肌球蛋白基因的组织方式，其结构的系统发育比较突出了这个多基因家族的进化。
