原肌球蛋白结构、调节、功能及病理学方面的新问题。

Emerging issues for tropomyosin structure, regulation, function and pathology.

作者信息

Gunning Peter

机构信息

Oncology Research Unit, Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

出版信息

Adv Exp Med Biol. 2008;644:293-8. doi: 10.1007/978-0-387-85766-4_22.

DOI:10.1007/978-0-387-85766-4_22

PMID:19209830

Abstract

There is a growing awareness of the role of tropomyosin in the regulation of the actin filament. Work in the field is increasingly directed at understanding the mechanisms of function at both a molecular and atomic level and developing therapeutic strategies to treat tropomyosin-based pathology. This chapter highlights unresolved issues that cross the boundaries between individual chapters and are likely to be fertile areas of research in the future.

摘要

人们越来越意识到原肌球蛋白在肌动蛋白丝调节中的作用。该领域的研究越来越多地致力于在分子和原子水平上理解其功能机制，并开发治疗基于原肌球蛋白的病理学的治疗策略。本章重点介绍了跨越各章节界限且可能在未来成为富有成果的研究领域的未解决问题。