新型手性噻吩-salen 铬配合物在不对称 Henry 反应中的应用。
New chiral thiophene-salen chromium complexes for the asymmetric Henry reaction.
机构信息
Equipe de Catalyse Moléculaire, ICMMO, UMR CNRS 8182, Université Paris-Sud 11, 91405 Orsay cedex, France.
出版信息
J Org Chem. 2009 Mar 6;74(5):2242-5. doi: 10.1021/jo802769y.
Chiral thiophene-salen chromium complexes were investigated in their monomeric form as soluble catalysts in the enantioselective Henry reaction of several aldehydes. The anodic polymerization of one complex led to an insoluble powder that was successfully used as a heterogeneous catalyst for the transformation of 2-methoxybenzaldehyde with enantiomeric excesses up to 77%. The polymerized catalyst was recovered and also recycled in an original multisubstrate procedure.
手性噻吩-席夫碱铬配合物作为可溶性催化剂，在几种醛的对映选择性 Henry 反应中进行了单体形式的研究。其中一个配合物的阳极聚合得到了一种不溶性粉末，该粉末成功地用作非均相催化剂，用于 2-甲氧基苯甲醛的转化，对映体过量最高可达 77%。聚合催化剂被回收并在原始的多底物程序中循环使用。
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