Filippova Liudmila, Stenstrøm Yngve, Hansen Trond Vidar
Department of Chemistry, Biology and Food Science, Norwegian University of Life Sciences, P.O. Box 5003, N-1432 Ås, Norway.
Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, P.O. Box 1068, Blindern, N-0316 Oslo, Norway.
Molecules. 2015 Apr 9;20(4):6224-36. doi: 10.3390/molecules20046224.
A novel C1-symmetric dinitrogen ligand was synthesized in high yield from commercially available (1R,2R,3R,5S)-(-)-isopinocampheylamine and 1-methyl-2-imidazolecarboxaldehyde. In combination with Cu(OAc)2H2O, this new ligand promote the reaction between nitromethane and aliphatic aldehydes with high yields (up to 97%) and moderate enantioselectivities (up to 67% ee). The reactions with benzaldehyde required prolonged reaction time that resulted in diminished yields, but accompanied with ee-values in the 55%-76% range.
一种新型的C1对称二氮配体由市售的(1R,2R,3R,5S)-(-)-异松莰基胺和1-甲基-2-咪唑甲醛高产率合成。与Cu(OAc)₂·H₂O结合，这种新配体促进硝基甲烷与脂肪醛之间的反应，产率高（高达97%），对映选择性适中（高达67% ee）。与苯甲醛的反应需要延长反应时间，这导致产率降低，但对映体过量值在55%-76%范围内。
