Mimoto T, Uchida K, Sakuraba S, Doi Y, Nukiwa T, Uekusa T, Kuwabara N, Inatomi K, Kira S
Department of Respiratory Medicine, Juntendo University, School of Medicine, Tokyo, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Jul;29(7):893-9.
A 51-year-old male was hospitalized in June 1983, complaining of productive cough and dyspnea. Diffuse panbronchiolitis (DPB) was diagnosed on the basis of the physical examination, chest roentgenogram, chest CT and transbronchial lung biopsy (TBLB). The patient underwent surgery for chronic sinusitis and deviated nasal septum, and received Pseudomonas aeruginosa vaccine, ampicillin and erythromycin. He revealed a posterior mediastinal tumor in March 1989. The clinical findings of DPB improved but open lung biopsy was performed on the occasion of surgery for the posterior mediastinal tumor. Pathologically, fibrosis and mild infiltration of mononuclear cells localized in the walls of respiratory bronchioli and in surrounding areas was recognized in addition to slight accumulation of foamy macrophages in interstitial spaces. These morphological findings, as well as the clinical findings, might suggest repair of DPB lesions.
一名51岁男性于1983年6月住院,主诉为咳痰和呼吸困难。根据体格检查、胸部X线片、胸部CT和经支气管肺活检(TBLB)诊断为弥漫性泛细支气管炎(DPB)。该患者接受了慢性鼻窦炎和鼻中隔偏曲手术,并接种了铜绿假单胞菌疫苗,使用了氨苄西林和红霉素。他于1989年3月发现后纵隔肿瘤。DPB的临床症状有所改善,但在进行后纵隔肿瘤手术时进行了开胸肺活检。病理检查发现,除间质中有少量泡沫状巨噬细胞聚集外,呼吸性细支气管壁及其周围区域有纤维化和轻度单核细胞浸润。这些形态学表现以及临床症状可能提示DPB病变的修复。